Buzhong Yiqi decoction prescription
Astragalus membranaceus18g; 9 grams of licorice; 6 grams of ginseng; 3 grams of angelica; 6 grams of orange peel; Cimicifuga 6 grams; 6 grams of Bupleurum; Atractylodes macrocephala 9 g
Buzhong Yiqi decoction prescription
This recipe treats syndromes caused by dietary fatigue and spleen and stomach damage, which leads to spleen and stomach qi deficiency and poor yang clearing. Spleen and stomach is the source of qi and blood biochemistry, spleen and stomach deficiency, loss of appetite, so diet is reduced and stool is thin. Spleen governs ascending, spleen deficiency rises, and middle qi sinks, resulting in proctoptosis and uterine prolapse. Qingyang is trapped in the lower jiao, and if depression is not suppressed, it will cause fever. Because it is not a real fire, the heat is not very high and the course of disease is long. Sometimes, the palm of your hand is hotter than the back of your hand, which is different from the endless heat caused by exogenous fever. Qi deficiency is not solid, and spontaneous sweating is caused by vaginal leakage. Treatment should supplement the qi of the spleen and stomach, promote yang and relieve depression. Astragalus membranaceus is reused in the prescription, which tastes sweet and slightly warm, enters the lung meridian, supplements the middle energizer, strengthens yang and consolidates exterior, and is the monarch drug. Ginseng, Radix Glycyrrhizae Preparata and Rhizoma Atractylodis Macrocephalae are ministers of invigorating qi and strengthening spleen, and they are used together with Radix Astragali to enhance their function of invigorating middle qi. Blood is the mother of qi, and if qi deficiency lasts for a long time, blood is also deficient, so angelica is used to replenish blood and nourish blood, and ginseng and astragalus are used to replenish qi and nourish blood; Pericarpium Citri Tangerinae regulates qi and stomach, so that all the medicines are supplemented without stagnation, and * * * is the auxiliary medicine. Use a small amount of Cimicifuga rhizome and Bupleurum root to relieve depression, and use monarch drugs to relieve depression. Compendium of Materia Medica says: Cimicifuga is the most important drug for introducing spleen and stomach meridians. * * * as an assistant. Roasted licorice is also a medicine to reconcile various medicines. The combination of various drugs can make qi deficiency be supplemented, qi sink rise and symptoms heal themselves. Fever due to qi deficiency is also eliminated by warming and tonifying qi. With regard to the theoretical basis of this prescription for treating fever due to qi deficiency, Li Dongyuan said: It is heat, not heat between the livers, but moisture from the spleen and stomach between the kidneys, which leads to the upwelling of yin fire and makes the steaming hot. ? Say it again: Deficiency of both spleen and stomach, lack of vitality and vigorous heart fire. Heart fire, yin fire, starts from the lower coke, is tied to the heart, and the heart does not take the lead, and fire replaces it; The fire that burns the envelope is the thief of vitality. Fire and vitality are at odds, and a victory is a defeat. ? (in the theory of internal injuries and traumas), it can be seen that this kind of fever, in Li Dongyuan's view, is? Yin fire? . Its essence is mainly deficiency and cold of spleen and stomach, abnormal ascending and descending, sinking of clearing yang, downward flow of spleen dampness, stagnation of yang qi in lower jiao, which leads to heat upwelling and insufficient chemical source. Take juice from a medium coke? If it is not enough to turn red into blood, then blood is not enough to nourish the heart, resulting in the image of heart-fire alone. Treat this fever. However, it is necessary to supplement it with a warm agent to nourish its yang, and the more it is diarrhea, it will be supplemented with a cold agent. ? Covering the temperature can dispel the summer heat and prevent the bitter and cold medicine from diarrhea in the stomach and ears! Today's Buzhong Yiqi Decoction was established. ? (Theory of Internal Injury and Trauma) To sum up, is Li established? Can the temperature remove heat? This theory expounds the syndrome differentiation, pathogenesis, treatment and taboo of exogenous fever and internal injury fever, which is helpful to deeply understand the connotation of this prescription and guide clinical application.
Literature of Buzhong Yiqi Decoction
Fang Luolun Mei's treatise on ancient and modern famous doctors 1:? Where the spleen and stomach are deficient in cold, the lung qi will fail first, so use Astragalus membranaceus to protect the pancreas and prevent spontaneous sweating; Lack of vitality, lazy talk and asthma, ginseng supplements it; The sweetness of roasted licorice can relieve annoyance by purging heart fire and replenish spleen and stomach. These three flavors are not only the holy medicine for annoying heat. Assisting Atractylodes macrocephala to strengthen the spleen; Angelica supplements blood; Chest obstruction and turbid stagnation are treated with dried tangerine peel, and various sweet drugs are used to disperse the stagnation; Qingqi sinks in the stomach. If Cimicifuga rhizome and Bupleurum root are lightly used, but the taste is light, it will induce the stomach qi to rise and return to its original position, so that it will rise and increase. Chinese medicine supplements can be made public, and Chinese medicine is safe; Yiqi agent depends on the product of clearing qi and supplementing qi twice. This medicine has its own advantages. ? Theory of internal injury and trauma:? Breathing high, body heat, heavy pulse, headache, or thirst, cold and hot skin. ?
Improved method of Buzhong Yiqi decoction
1. Blood deficiency-Angelica sinensis.
2. Mental deficiency-Ginseng and Schisandra chinensis.
3. Lung heat cough-ginseng removal.
4. Dry Radix Puerariae.
5. Headache-add Vitex negundo and Ligusticum chuanxiong to relieve pain.
6. brain pain -plus? Ben Asarum.
7. rheumatism beats each other and hurts all over-plus notopterygium and windproof.
8. Eliminating phlegm-add Pinellia ternata and ginger.
9. Stomach cold and qi stagnation-add green tangerine peel, cardamom, costustoot and Alpinia oxyphylla.
10. Abdominal distension-Radix Paeoniae Alba and Radix Glycyrrhizae are added.
1 1.
12. You can eat but your heart is swollen-Coptis chinensis.
13. Pharyngalgia-Platycodon grandiflorum.
14. Add cinnamon cold.
15. Wet wins-Atractylodes lancea.
16. Yinhuo-add Cortex Phellodendri, Radix Rehmanniae Preparata and Rhizoma Dioscoreae.
17. Remove yin deficiency and Cimicifuga foetida, and add Radix Rehmanniae Preparata, Fructus Crataegi and Rhizoma Dioscoreae.
18. Constipation-add wine to simmer rhubarb.
19. Cough relieving: Rhizoma Drynariae and Flos Farfarae are added in spring, Radix Ophiopogonis and Five Flavors are added in summer, Herba Ephedrae and Scutellariae Radix are added in autumn, Herba Ephedrae is not removed in winter, and dried ginger is added in cold weather.
20. antidiarrheal-go to angelica, add poria cocos, atractylodes rhizome and yizhi.
Pharmacological Effects of Buzhong Yiqi Decoction
1. Yiqi Jianpi
Li et al. found that the gastric parietal cells in rats with spleen deficiency induced by rhubarb were obviously dilated secretory tubules under electron microscope, with dense microvilli, few vesicles and no abnormal mitochondrial structure, suggesting that the ultrastructure of gastric parietal cells in rats with spleen deficiency was in a state of stress, and Buzhong Yiqi Decoction could restore its abnormal changes in ultrastructure.
He Zheng's research shows that the binding sites of gastrin receptor in gastric parietal cells of rats with spleen deficiency are obviously reduced, which leads to the decrease of gastric mucosal defense and the increase of sensitivity to attack factors. At the same time, the content of nitric oxide in gastric mucosa decreased. Buzhong Yiqi decoction can increase the binding site of gastrin receptor, increase the content of nitric oxide in gastric mucosa and increase the content of gastrin in rats with spleen deficiency.
It was also found that calmodulin (CaM), calcium/calmodulin dependent protein kinase Ⅱ (Ca2+/calmodulin independent protein kinase Ⅱ, Ca2+/CAM? PK Ⅱ) activity increased significantly, suggesting that parietal cells of rats with spleen deficiency were in a state of high stress. Buzhong Yiqi decoction can reduce calmodulin and Ca2+/ calmodulin in parietal cells of rats. PKII activity can decrease the content of Ca2+ in parietal cells and increase the content of inositol triphosphate (IP3) in parietal cells, suggesting that part of the mechanism of Buzhong Yiqi Decoction in regulating spleen deficiency syndrome may be realized through the intracellular signal transduction of receptors and receptors. The above research suggests that the mechanism of Buzhong Yiqi Decoction in invigorating qi and spleen may involve improving the tissue structure of digestive tract and affecting the signal transduction of digestive tract.
2. Warm and clear away heat
Zhang En and Qin Zhao households, right? Lack of biochemical sources? Methods The rabbit model of spleen deficiency was reproduced, and the same exogenous heat source was given to the rabbits with spleen deficiency and normal rabbits to induce fever, and the response to the same pathogenic factor stimulation in different body States was observed. The results showed that the latent period and heat course of fever in rabbits with spleen deficiency were longer, and fever continued in the later period, reflecting the pathological state that healthy qi could not drive away evil spirits and evil spirits were entrenched in the later period of fever. Buzhong Yiqi decoction has obvious antipyretic effect on experimental spleen deficiency fever in rabbits, which can inhibit the increase of body temperature, relieve heat potential and shorten the course of heat. Judging from the influence of Buzhong Yiqi decoction on the body temperature of rabbits with normal fever and rabbits with spleen deficiency, Buzhong Yiqi decoction can reduce the body temperature of the two rabbits, but it has obvious effect on the fever of rabbits with spleen deficiency in terms of heat course, heat potential and fever peak, suggesting that Buzhong Yiqi decoction is right? Qi deficiency and evil invasion? Fever has a good effect. The antipyretic mechanism may be related to the decrease of E2 (prostaglandin E2, PGE2) in cerebrospinal fluid and camp in preoptic area of hypothalamus.
3. Protect organ function
Chen et al. established an immune liver disease model in Nc/ Jic mice sensitized by ovalbumin, and found that liver histopathology was significantly improved, serum alanine aminotransferase was significantly reduced, and interleukin -4(interleukin? 4，IL4)、IL？ 6.CD4 decreased obviously, suggesting that Buzhong Yiqi decoction can improve immune liver injury. Ochi et al reported that Buzhong Yiqi decoction can inhibit the increase of hydroxyproline caused by pig serum, reduce the deposition of collagen type ⅳ in liver, and inhibit serum or liver prolyl? 4? Hydroxylase activity, inhibiting fibroblast growth factors such as transforming growth factor? (transforminggrowthfactor？ ，TGF？ ) and IL? The production of 13 shows that Buzhong Yiqi decoction can improve liver fibrosis.
Liu et al. used Buzhong Yiqi Decoction to treat chronic obstructive pulmonary disease. The results showed that the effective rate of Buzhong Yiqi decoction was 73.3%, and the lung function was obviously improved after treatment, suggesting that Buzhong Yiqi decoction can reduce airway hyperresponsiveness, reduce airway resistance and improve lung ventilation, thus improving the lung function of patients with acute exacerbation. Tajima et al. found that Buzhong Yiqi decoction can significantly reduce the mortality rate of rats with lung injury caused by bleomycin, reduce the content of hydroxyproline and fluid in lung tissue, reduce the infiltration of lung tissue cells, alleviate pulmonary fibrosis, improve lung tissue structure and regulate lung IL? 5 and interferon? It is suggested that Buzhong Yiqi decoction may improve pulmonary fibrosis by adjusting the ratio of Th 1/Th2. Tajima et al. also found that Buzhong Yiqi decoction can reduce the total cell number, neutrophil number and macrophage number in bronchoalveolar fluid of lipopolysaccharide-induced acute lung injury model. Increase serum keratinocyte inducing factor (KC); Histological examination showed that the infiltration of white blood cells in lung tissue decreased, suggesting that Buzhong Yiqi Decoction has certain lung protection effect.
Kim and other studies have confirmed that Buzhong Yiqi decoction has radiation protection effect and can protect it? Ginseng, Angelica sinensis, Cimicifuga rhizome and Bupleurum root are the main components of radiation protection for intestinal tract and hematopoietic organs, but their intensity is not as good as Buzhong Yiqi decoction.
The above research suggests that Buzhong Yiqi decoction has many normal tissue protection functions, including liver, lung, bone marrow and gastrointestinal tract, and its mechanism may be related to immunity.
4. Improve bone metabolism
Lin Jiantao and others found that the maximum load, elastic load and stiffness coefficient of bone biomechanics index in the model group decreased, but the coefficient of Buzhong Yiqi decoction increased obviously after treatment, and its strength was equivalent to that of calcium gluconate, suggesting that Buzhong Yiqi decoction can resist the decline of bone quality caused by cyclophosphamide and prevent osteoporosis. Sakamoto et al. found that Buzhong Yiqi decoction can increase the decrease of bone mineral density caused by Busherelin acid gonadotropin-releasing hormone agonist and increase serum estradiol level, suggesting that Buzhong Yiqi decoction can be used for abnormal bone metabolism caused by ovarian chemical castration. Sassa et al. found that Buzhong Yiqi decoction can inhibit the decrease of bone mineral density caused by ovariectomy and increase the levels of serum estradiol and progesterone, suggesting that Buzhong Yiqi decoction can inhibit the bone loss caused by ovarian hormone reduction. Song and other studies also confirmed that Buzhong Yiqi Decoction can improve the level of estradiol, reduce alkaline phosphatase, reduce the ratio of blood calcium to phosphorus and eliminate urinary calcium in rats under microgravity environment, suggesting that Buzhong Yiqi Decoction can improve bone metabolism.
5. Anti-infertility
Yoshida and others confirmed that Buzhong Yiqi Decoction can improve the concentration, quantity, density and fluidity of semen. The clinical effective rate of treating oligospermia infertility can reach 5 1. 1%, and the pregnancy rate can reach 20%. Subsequently, Sudo and other studies found that Buzhong Yiqi Decoction can effectively improve the spermatogenic defects caused by adriamycin, including the reduction of testicular weight and the number of spermatogenic tubes. Amano et al. confirmed that Buzhong Yiqi decoction can effectively improve sperm motility in vitro, but it does not affect sperm fluorescence parameters. Daxi et al. found that Buzhong Yiqi decoction can obviously improve semen soluble Fas and reduce semen IL? Level 6, but does not change IL? The level of 8. Furuya et al. applied Buzhong Yiqi decoction to spontaneous male infertility on the basis of traditional syndrome differentiation, and found that Buzhong Yiqi decoction can effectively improve sperm quantity and exercise ability, and increase the level of soluble Fas in semen, and pointed out that the application of traditional Chinese medicine needs syndrome differentiation and treatment.
6. Anti-prostatic hyperplasia
Liao et al. used subcutaneous injection of testosterone propionate to induce prostatic hyperplasia in ovariectomized rats. It was found that after using Buzhong Yiqi Decoction, the prostate epithelial cells of rats shrank, the surface wrinkles of acinus disappeared, the glandular cavity was smooth, the glandular epithelium was mostly single-layer flat epithelium, the nucleus was small and round, the glandular stroma was few, the distribution was sparse and the basal smooth muscle was few. The wet weight of prostate, prostate index and serum acid phosphatase were significantly lower than those in the model group, suggesting that Buzhong Yiqi Decoction can obviously inhibit the activity of serum acid phosphatase in rats and inhibit prostatic hyperplasia in rats. Buzhong Yiqi decoction can be used to treat benign prostatic hyperplasia in clinic.
7. Others
Wang et al. established a mouse model of fatigue syndrome by aborting Brucella. Buzhong Yiqi decoction can improve the daily activities of model mice, increase body weight and weight/spleen weight ratio, and inhibit spleen IL? 10 expression. Shih et al. found that Buzhong Yiqi decoction can improve the exercise endurance, neuromuscular coordination, learning and memory ability of mice in a dose-dependent manner, and can increase the levels of dopamine and norepinephrine in muscle tissue, suggesting that Buzhong Yiqi decoction has certain anti-aging effect.