Sleep is very important to the human body. According to statistics, the incidence of sleep-wake disorder worldwide is 9%- 15%. 20 15 China's sleep index report shows that about 3 1.2% people in China have serious sleep problems [1].

There is even a punk health party that "stays up the longest with the most expensive eye cream", but can staying up late really be saved with the "most expensive eye cream"?

In fact, this is not the case.

What your brain does during rest may be more important than other times.

Because some studies have found that lack of sleep may affect the disease process of patients with Alzheimer's disease. More and more evidences show that the change of normal sleep patterns will promote the appearance of β -amyloid (Aβ) and Tau protein aggregates, and gradually deposit in the brains of AD patients. The main protein precipitates leading to AD pathology are Aβ and Tau proteins.

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Sleep deprivation and pathological protein of AD

An article published in the journal Science this year studied the effects of sleep on the levels of Aβ protein and Tau protein in the brains of mice and humans [2]. It was found that wild-type mice usually spend 60% of their time sleeping. When they sleep normally, the level of Tau protein in the interstitial fluid (ISF) of hippocampus is low, but when the awake time of mice reaches 70%, the level of ISF in the same area is the same as that of Tau protein.

Figure 1: After artificial sleep deprivation (SD),

Daily change and increase of ISF and tau protein (*p