The high incidence age of hyperuricemia is middle-aged and elderly men and postmenopausal women, but in recent years, hyperuricemia has become an important risk factor for metabolic diseases and cardiovascular diseases. Therefore, as a Buddhist health care family, the first step is to be careful of high uric acid!

For a long time, serum uric acid is an important biochemical index used to diagnose and evaluate gout patients. However, in recent years, many studies have proved that hyperuricemia is not only a detection index of gout and complicated renal damage, but also closely related to cardiovascular diseases and metabolic diseases [1]. Studies have confirmed that hyperuricemia can promote arteriosclerosis and platelet aggregation, and accelerate the deposition of lipids on blood vessel walls. Uric acid can damage the intima of arteries and cause vascular endothelial dysfunction. According to the survey, there are about 65.438+0.2 billion patients with hyperuricemia in China, accounting for 654.38+00% of the total population, which needs to be highly valued by both doctors and patients.

1. Uric acid and coronary heart disease

Because of the low physical solubility of uric acid, uric acid crystals are easy to precipitate in blood, and the precipitated uric acid crystals attach to the blood vessel wall, which directly damages the microvascular function of coronary artery. Uric acid crystallization can also activate platelets, make platelets aggregate and promote thrombosis. In addition, uric acid can deposit lipids in the intima of arteries, promote atherosclerosis and plaque formation, and thus lead to the occurrence and development of coronary heart disease. The investigation shows that when the serum uric acid level is ≥ 357 mmol/L, the risk of coronary heart disease will increase, and the mortality rate of coronary heart disease in hyperuricemia group is 2.5 times higher than that in hypouricemia group, especially in women [2].

2. Uric acid and hypertension

Uric acid destroys vascular endothelial function, causes vasodilation dysfunction, increases vascular resistance, hardens blood vessels, and raises blood pressure. About 30% patients with essential hypertension are accompanied by hyperuricemia. It was found that every increase in serum uric acid 100μmol/L increased the risk of hypertension by 23%[3]. On the other hand, due to the increase of blood pressure and the decrease of renal blood flow in hypertensive patients, uric acid reabsorption in renal tubules increases and hyperuricemia develops. That is, hyperuricemia can cause hypertension, and hypertension is the trigger of hyperuricemia.