Injection of strontium chloride has no effect, and bone metastasis is further aggravated, causing bone pain. Suggestion: 1. Three-step analgesic principle relieves pain. 2. Women, lung adenocarcinoma and Asians are the dominant groups taking gefitinib or erlotinib. It is recommended to take gefitinib, which has little side effects and the effective rate is about 60%. 3. Isotope therapy for bone metastasis is ineffective in most cases, but bone marrow suppression is serious and lasts for a long time. Attention should be paid to routine blood examination.