1955, the Moscow Academy of Medical Sciences declared Inonotus obliquus as an anticancer substance, and the government approved Inonotus obliquus for drug development. Inonotus obliquus is listed as a "special natural substance" in the United States as a drink for future astronauts. Japan used Inonotus obliquus as a therapeutic agent for liver cancer, AIDS and 0- 157 Escherichia coli poisoning, and applied for a number of patents on Inonotus obliquus.
Inonotus obliquus is a medicinal fungus mainly produced in Russia, which contains many active substances such as triterpenes from lanosterol, Inonotus obliquus alcohol, Inonotus obliquus, polysaccharides, lignin, alkaloids, tannic acid and melanin. Inonotus obliquus has been used in various intractable diseases, and its main medicinal part is sclerotium. A large number of pharmacological experiments show that Inonotus obliquus has the functions of antioxidation, blood lipid regulation, anticancer (liver cancer, stomach cancer, lung cancer, cervical cancer, breast cancer and rectal cancer), diabetes treatment, antivirus, anti-aging and immunity enhancement.
Functional characteristics of Inonotus obliquus;
1, anticancer effect
The effect of Inonotus obliquus polysaccharide on the proliferation of Jurkat and Daudi cells was detected by MTT assay, and Jurkat tumor-bearing nude mice model was established to study the anti-tumor effect of Inonotus obliquus polysaccharide on tumor-bearing nude mice. The results showed that Inonotus obliquus polysaccharide could directly kill Jurkat and Daudi tumor cells in vitro, with the highest inhibition rates of 62.29% and 66.42% respectively, and had a good dose-effect relationship. At the same time, it has significant anti-tumor activity in vivo. The inhibition rates of large and small doses on Jurkat tumor were 43.52% and 57.48% respectively, and the spleen index of nude mice could be significantly improved. Inonotus obliquus polysaccharide has obvious anti-tumor effect.
2. Liver protection
Inonotus obliquus polysaccharide acted on tumor-bearing mice. It was found that Inonotus obliquus polysaccharide (IOPS) had no obvious inhibitory effect on LO2 of normal liver cells, while Inonotus obliquus polysaccharide (IOPS) could obviously improve the deformation and necrosis of liver cells in tumor-bearing mice and had a significant protective effect on liver.
3. Hypoglycemic effect
Experiments show that Inonotus obliquus polysaccharide can effectively alleviate the symptoms of weight loss and blood sugar increase in diabetic mice, improve the activities of plasma insulin and pyruvate kinase in mice, promote glucose absorption and accelerate glucose metabolism. Inonotus obliquus intracellular polysaccharide significantly increased glycogen synthesis in liver and muscle of mice, inhibited glycogen degradation and increased glycogen content in tissues. It can be seen that Inonotus obliquus may inhibit glycogen metabolism, accelerate glycogen synthesis and increase sugar consumption in peripheral tissues by affecting the absorption, uptake, metabolism and degradation of glucose in vivo, thus achieving the purpose of reducing blood sugar in mice.
4. Antioxidant activity
The antioxidant activity was determined by FRAP, DPPH and ABTS+. The results showed that when the concentration of total flavonoids was 200 μ g/M L, the total antioxidant capacity of Inonotus obliquus was equivalent to 464.53μmol/L ferric sulfate, and the EC50 of DPPH radical scavenging rate was 36.44 μ g/ml. The EC50 of radical scavenging rate of ABTS+ is 299.89 μ g/m l. The scavenging rate of flavonoids from Inonotus obliquus to DPPH and ABTS+ is close to that of vitamin C(VC), and it has strong antioxidant activity, so it has the potential to be popularized as a natural antioxidant.
5. Adjust immunity
It is found that the water extract of Inonotus obliquus can reduce the activities of LDH, HBDH, MDH and GCT, increase the activity of catalase, scavenge free radicals in vivo, protect cells, prolong the division generation of subcultured cells, prolong cell life and promote metabolism, so long-term administration can effectively delay aging and prolong life.
6. Other functions
According to Japanese reports, Inonotus obliquus has certain therapeutic effects on vomiting, diarrhea, gastrointestinal dysfunction, gastric and duodenal ulcers, hepatitis, gastritis and nephritis. It has a certain preventive and therapeutic effect on osteopathy caused by unreasonable diet. Inonotus obliquus can also prevent and treat hypertension, and it is also a blood cleaner and analgesic, and also has a certain effect on skin allergy.