2 Yitong Pill Pharmacopoeia Standard 2. 1 is called Yitong Pill.
Xitong pill
2.2 The prescription of Herba Siegesbeckiae is 250g, and the stinky sliced leaves is 500g.
2.3 pulverize the above two ingredients, namely, 75g of Herba Siegesbeckiae and 0/50g of stinky plane leaves/kloc-into fine powder for later use; Decocting the remaining Herba Siegesbeckiae and Platanus acerifolia leaves in water for two times, mixing decoctions, filtering, and concentrating the filtrate to a fluid extract with a relative density of 65438 0.30 (80℃); Adding the above fine powder, mixing, drying, pulverizing, sieving (coating as appropriate), making pills with water, drying, and coating.
2.4 Characteristics This product is a black concentrated water pill; After removing the coating, it looks brown and tastes slightly bitter.
2.5 Identification (1) Take this product 1g, grind it, add 25ml of methanol, perform ultrasonic treatment for 30 minutes, let it cool, filter, evaporate the filtrate, add 20ml of water to dissolve the residue, shake and extract with ethyl acetate twice, 20ml each time, combine the ethyl acetate solutions, and shake and extract with 5% sodium carbonate solution twice, 20ml each time. In addition, take 65,438+0g of stinking plane leaves as reference medicinal material, add water to decoct for 65,438+05min, cool, filter, concentrate the filtrate to about 20ml, and prepare the reference medicinal material solution by the same method starting from "shaking and extracting with ethyl acetate twice". According to the test of thin-layer chromatography (appendix ⅵ b of Pharmacopoeia I, 20 10), absorb 5 ~ 10μ l of the above two solutions, respectively spot them on the same silica gel G thin-layer plate, and use toluene-ethyl acetate-formic acid (5: 2: 1) as developing agent, unfold, take out and dry. In the chromatogram of the test sample, the fluorescent main spots with the same color are displayed at the positions corresponding to the chromatogram of the control medicinal materials.
(2) Take this product and test it according to the method under 【 Content Determination 】. The chromatographic peak of the test sample should have the same retention time as that of the octanol reference sample.
2.6 The inspection shall comply with the relevant provisions under Pills (Appendix of Pharmacopoeia 20 10/A).
2.7 the content was determined by high performance liquid chromatography (appendix ⅵ D of pharmacopoeia I, 20 10).
2.7. 1 chromatographic conditions and system applicability test, using octadecylsilane bonded silica gel as filler; The mobile phase was acetonitrile-water-glacial acetic acid (25: 75: 0.1); The detection wavelength is 2 15 nm. According to the peak value of octanol, the theoretical plate number should be not less than 3000.
2.7.2 Preparation of reference solution Take an appropriate amount of n-octanol reference substance, accurately weigh it, and add methanol to make a solution containing 0. 1ml.
2.7.3 Preparation of test solution Take this product, grind it, weigh about 65438±0g, weigh it accurately, put it in Soxhlet extractor, add appropriate amount of ethanol, reflux extract until the extract is colorless, cool, recover ethanol from the extract until it is dry, add 25ml of water to the residue, dissolve it with slight heat, shake it evenly, extract it with water-saturated n-butanol for three times, 25ml for each time, combine the n-butanol extracts, and use.
2.7.4 Determination method Accurately absorb 20μl of control solution and 20μ l of test solution respectively, inject them into a liquid chromatograph, and determine to obtain the final product.
Every 65438 0 g of this product contains Herba Siegesbeckiae, calculated by n-octanol (C20H34O4), not less than 0.25mg.
2.8 Indications: clearing away heat and promoting diuresis, expelling wind and relieving pain. Used for rheumatic joint pain, characterized by joint swelling and heat pain; Rheumatoid arthritis with the above syndrome.
2.9 Oral administration and dosage. 10 pills once, three times a day.
2. 10 Caution should be given to patients with cold-heat arthralgia; Avoid spicy and greasy food.
2. 1 1 specifications 10 pill weight1.6g.
2. 12 storage seal.
2. 13 edition of China Pharmacopoeia 20 10 edition.
3 Jishi Health Collection Volume 3 Zhitong Pill 3. 1 Herb Siegesbeckiae.
3.2 In the preparation method, the medicated wine is dried in the sun to form fine powder, and honey is refined into pills.
3.3 Function Indications Yitong Pill, Volume III of Jishi Health Collection, has the effects of expelling wind and removing dampness, relaxing muscles and activating collaterals. Indications: rheumatism, soft feet, difficulty in walking, like wind paralysis. Now it is used for rheumatoid arthritis and chronic lumbocrural pain.
3.4 Usage and dosage of Yitong Pill: each time 12g, one pill in the morning and one pill in the evening.
3.5 attention