Polygonatum sibiricum is a traditional health care product, and its health care function has always been highly respected. It is recorded in "Seeking the Source of Materia Medica" that the Yellow Sutra has the functions of eliminating yellow qi, calming yellow leaves and making fish and gems. Many Chinese medicines are still brewed with Polygonatum sibiricum to improve their efficacy.
However, for many years, the research and publicity of Huangjing Liquor has been stuck at the level of protein, amino acids and other conventional nutrients, which is extremely disproportionate to the development of science and technology today, and it is impossible to scientifically explain its health-preserving function, resulting in the health-preserving function of Huangjing Liquor being gradually ignored by people.
One is rich in phenols.
Phenolic substances are considered to have physiological functions such as scavenging free radicals, preventing cardiovascular diseases, resisting cancer and resisting aging.
Second, high content of functional oligosaccharides.
Functional oligosaccharides are not easily digested by human body, and produce little or no heat after ingestion, but can be used by beneficial microorganism Bifidobacterium in intestinal tract, which can promote the proliferation of Bifidobacterium, improve intestinal microecological environment, promote the synthesis of B vitamins and the absorption of minerals such as calcium, magnesium and iron, improve immunity and disease resistance, decompose intestinal endotoxin and carcinogens, prevent various chronic diseases and cancers, and reduce serum cholesterol and blood lipid levels.
Third, unparalleled bioactive peptides.
Recent studies show that oligopeptides composed of several amino acids have better absorption characteristics than amino acids, and many peptides have physiological functions that protein or its constituent amino acids do not have, such as promoting calcium absorption, lowering blood pressure, lowering cholesterol, calming the nerves, regulating immunity, resisting oxidation, scavenging free radicals, and resisting cancer.
Pathogenic microorganism action
Polygonatum sibiricum has inhibitory effect on acid bacteria in test tubes. For guinea pigs with experimental tuberculosis, the drug was given at the same time when infected with mycobacterium tuberculosis, and then given to guinea pigs with swollen lymph nodes after infection, all of which had obvious bacteriostatic effect, obviously improved their health status and the curative effect was close to isoniazid. It has only a weak inhibitory effect on typhoid Bacillus (the minimum inhibitory concentration is 500- 1000 mg%). More than 2% ethanol extract of Polygonatum sibiricum has inhibitory effects on many common pathogenic fungi to varying degrees. The concentration of L: L0 can slow down glands and viruses and inhibit herpes virus.
The effect of Polygonatum sibiricum on cardiovascular system, water extract, ethanol monohydrate extract and 30% ethanol extract all have the effect of lowering blood pressure of anesthetized animals. Polygonatum alcohol preparation can increase the coronary flow of dogs in vivo, which is equivalent to aminophylline 0.75 mg/kg, and has no obvious effect on femoral artery pressure, heart rate and central venous pressure. 0. 15% Polygonatum alcohol preparation can enhance the contractility of isolated toad heart, but has no obvious effect on heart rate, while 0.4% Polygonatum alcohol solution or water solution can accelerate the heart rate of isolated rabbit heart.
3. Effects on blood lipid and blood glucose The experimental hyperlipidemia rabbits were given 100% Polygonatum decoction, 5ml each time, twice a day for 30 days. Compared with the control group, 10, 20 and 30 days after administration, triglyceride, β-lipoprotein and blood cholesterol decreased significantly. Polygonatum sibiricum extract has a significant inhibitory effect on adrenaline-induced hyperglycemia.
1. Antibacterial effect: In vitro experiments show that the extract of Polygonatum sibiricum (1: 320) has inhibitory effects on typhoid Bacillus, Staphylococcus aureus and acid-fast Bacillus, and 2% Polygonatum sibiricum has inhibitory effects on common pathogenic fungi in sabouraud medium to varying degrees.
2. Effect on blood sugar: The blood sugar content of Polygonatum sibiricum extract in rabbits increased at first and then decreased. Polygonatum sibiricum extract has a significant inhibitory effect on adrenaline-induced hyperglycemia.
3. Anti-fatigue effect: intraperitoneal injection of Polygonatum sibiricum 17.67% 0.3ml/ mouse can prolong the swimming time of mice.
4. Antioxidant effect: 20% concentration of Huangjing decoction, 65,438+0.3 ml/drink for 27 days, can improve the activity of superoxide dismutase in liver and reduce the content of lipofuscin in myocardium.
5. Anti-aging effect: 20% mulberry leaves soaked in Polygonatum decoction can prolong the larval stage of silkworm.
6. Hemostasis: 40mg/ of Polygonatum sibiricum methanol extract, 20 mg of n-butanol and 20 mg of water layer were injected intraperitoneally, and the tail of mice was frozen with dry ice-methanol for 65438 0 minutes. The experiment of tail-cutting method shows that it has hemostatic effect and reduces the bleeding amount of mice.
7. Effect on cardiovascular system: Intravenous injection of water extract of Semen Astragali (0. 1.6-0.26 g/kg) significantly increased the coronary flow of anesthetized dogs; Intravenous injection 1.5g/kg can antagonize myocardial ischemia caused by pituitrin in rabbits, antagonize the increase of T wave caused by pituitrin, and promote the early recovery of abnormal T wave. Intraperitoneal injection of 12g/kg can enhance the tolerance of mice to hypoxia.
8. Antiviral effect: Polygonatum polysaccharide 0.2% eye drops, 6 times a day, or Polygonatum polysaccharide 10mg/kg, twice a day, has therapeutic effect on experimental herpes simplex keratitis in rabbits.
9. Other effects: Polygonatum sibiricum decoction 6g/kg 10 day can improve the activities of Na+ and K+-ATPase in erythrocyte membrane of mice. Intraperitoneal injection of 40% ethanol extract of Polygonatum sibiricum (0.3ml/ mouse) can increase the incorporation rate of 3H-TdR in myocardial, liver and spleen cells of mice. Polygonatum sibiricum decoction (0.5g/ g) decreased the contents of cAMP and cGMP in plasma of mice, but cGMP decreased more, so the ratio of cAMP to cGMP was higher than that of the control group, and the contents of camp and CGMP in spleen increased, but the ratio of camp to CGMP did not change significantly.