Xinkeshu tablet is composed of Fructus Crataegi, Radix Salviae Miltiorrhizae, Radix Puerariae, Radix Notoginseng and Radix Aucklandiae. Its main functions are promoting blood circulation, removing blood stasis, promoting qi circulation and relieving pain. It is suitable for chest distress, palpitation, dizziness, headache, neck pain, angina pectoris, hypertension, hyperlipidemia and arrhythmia caused by qi stagnation and blood stasis. Modern pharmacological research shows that taking Xinkeshu tablets can improve the hypoxia tolerance of patients' myocardium, protect ischemic myocardium, dilate blood vessels, lower blood pressure, lower cholesterol and prevent thrombosis.
Notoginseng Radix and Salviae Miltiorrhizae Radix have the effects of anticoagulation, promoting the function of fibrinolytic system and preventing thrombosis. Danshensu and tanshinone in Salvia miltiorrhiza can inhibit the absorption of exogenous cholesterol and improve the metabolism of phospholipids in the liver. Puerarin in Pueraria lobata can increase prostaglandin and high density lipoprotein cholesterol (good cholesterol) which can dilate blood vessels, and decrease the level of thromboxane A2 which can promote thrombosis. Hawthorn digestion, qi and phlegm; Radix aucklandiae promotes qi and blood circulation. Therefore, Xinkeshu tablets can reduce various indexes related to blood viscosity, such as total cholesterol, low-density lipoprotein cholesterol and triglyceride. By preventing platelet aggregation, the blood supply and oxygen supply to the heart of patients can be improved and the related symptoms of coronary heart disease can be eliminated.
Yangxinshi tablet consists of Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Puerariae, Herba Epimedii, Fructus Crataegi, Radix Rehmanniae, Radix Angelicae Sinensis, Rhizoma Coptidis, Rhizoma Corydalis (baked), Ganoderma, Radix Ginseng and Radix Glycyrrhizae (baked). It has the effects of strengthening body resistance, invigorating qi, promoting blood circulation, dredging collaterals and relieving pain, and is suitable for patients with coronary heart disease, angina pectoris, myocardial infarction, hyperlipidemia and hyperglycemia of qi deficiency and blood stasis type.
Hyperlipidemia causes increased blood viscosity, slow blood circulation, decreased arterial blood flow and enhanced coagulation function, which is the main cause of ischemic heart disease. Studies have shown that Yangxinshi tablet can reduce blood lipid, prevent atherosclerosis, significantly reduce serum C-reactive protein (inflammatory index), thus reducing the inflammatory response of coronary atherosclerotic plaque, improving myocardial ischemia and relieving angina pectoris.
Tongxinluo Capsule consists of Ginseng Radix, Hirudo, Scorpio, Radix Paeoniae Rubra, Periostracum Cicadae, Eupolyphaga Seu Steleophaga, Scolopendra, Lignum Dalbergiae Odoriferae, Olibanum (processed), Semen Ziziphi Spinosae (fried) and Borneolum Syntheticum. In the prescription, ginseng is used to strengthen the heart and promote blood circulation; Leech promotes blood circulation to remove blood stasis and dredge meridians; Eupolyphaga Seu Steleophaga removes blood stasis and unblocks collaterals; Insecticides such as scorpion, centipede and cicada slough. Being good at walking can induce various drugs to dredge meridians and relieve spasms; Radix Paeoniae Rubra promotes blood circulation, removes blood stasis and relieves pain; Borneolum fragrance powder, so that congestion unobstructed. The compatibility of various drugs complements each other, playing the role of benefiting qi and promoting blood circulation, dredging collaterals and relieving pain.
Tongxinluo capsule has the main functions of benefiting qi and promoting blood circulation, dredging collaterals and relieving pain. Angina pectoris, suitable for coronary heart disease, is a syndrome of heart-qi deficiency and blood stasis blocking collaterals, characterized by chest tightness, tingling, colic, immobility, palpitation, spontaneous sweating, shortness of breath and fatigue. The tongue is dark purple or ecchymosis, and the pulse is fine and astringent or knotted. It can also be used for apoplexy due to qi deficiency and blood stasis and obstruction of collaterals. The patient showed hemiplegia, numbness, crooked mouth and tongue, and bad speech.
Animal experiments show that Tongxinluo capsule can improve coagulation function and microcirculation disturbance, not only reduce the specific viscosity of whole blood, improve hemorheology and protect endothelial cells, but also delay and prevent coagulation process by reducing the synthesis of fibrinogen in liver, thus playing an anticoagulant role. Tongxinluo capsule can regulate dyslipidemia, which is obviously better than atorvastatin in regulating high density lipoprotein cholesterol, and can also improve the ability of vascular endothelial cells to resist hypoxia injury.
In a word, Xinkeshu tablets, Yangxinshi tablets and Tongxinluo capsules used to treat coronary heart disease all have relevant evidence-based medical evidence, which has been proved to be safe and effective by clinical practice, but individual selection is needed on the basis of comparing indications and syndrome differentiation.