Therefore, correcting the disorder of lipid metabolism is of great significance for preventing the occurrence of cardiovascular and cerebrovascular diseases and improving the prognosis of patients. Xuezhitong capsule, Maixuekang capsule and Xuezhikang capsule are all derived from the extract of a single component, with little side effects, and have good curative effects on cardiovascular and cerebrovascular diseases caused by hyperlipidemia.
Xuezhitong capsule is a lipid-lowering drug made from the extract of natural plant Allium macrostemon, which is homologous to medicine and food. It has the effects of activating yang, dispersing stagnation, widening chest, regulating qi, promoting qi circulation and guiding stagnation, and is suitable for chest tightness, fatigue, abdominal distension and fullness caused by hyperlipidemia, blood stasis and phlegm obstruction. The medicine achieves therapeutic effect by inhibiting the production of endogenous total cholesterol and accelerating the catabolism of total cholesterol and triglyceride. It is a dual-purpose drug with high safety and no toxic or side effects, and can be taken for a long time.
Modern pharmacological experiments have proved that the main components of Allium macrostemon Bunge include sulfur-containing compounds such as methyl allyl sulfur, which can inhibit thrombosis, effectively reduce blood lipid and total cholesterol, inhibit platelet aggregation and thromboxane A2 synthesis, and have significant anti-atherosclerosis effect. After treatment with Xuezhitong capsule, the patients can effectively protect myocardial ischemia-reperfusion and prevent atherosclerosis. It has the function of reducing blood fat, has no damage to the liver, has high medication safety and can be tolerated by patients.
Maixuekang capsule is mainly composed of leeches, which has the effects of breaking blood, removing blood stasis, dredging veins and relieving pain. Suitable for abdominal mass, blood stasis amenorrhea, traumatic injury, etc. Clinically, it is mainly used to treat cardiovascular and cerebrovascular diseases, peripheral vascular diseases, diabetes and its complications, and plays an important role in the treatment of gynecological, otorhinolaryngology and ophthalmology diseases. It can effectively relieve the pathological processes such as ischemia, hypoxia, necrosis, blood stasis and edema, and has the functions of anticoagulation, antithrombosis and anti-fibrosis. The method of breaking blood, removing blood stasis and dredging collaterals, represented by this prescription, has outstanding curative effect in improving the circulation of large blood vessels and microvascular.
Modern pharmacological research shows that hirudin, the main active substance in leeches, is the strongest natural direct thrombin inhibitor, which can effectively exert antithrombin activity and fibrinolytic activity. By regulating lipid metabolism, correcting the disorder of serum NO metabolism and inhibiting the expression of intercellular adhesion molecules in aortic wall, vascular endothelium can be protected and the formation of atherosclerosis can be intervened. In addition, it can also affect hemorheology and improve circulatory disorders by reducing whole blood viscosity, platelet aggregation rate and prolonging coagulation time. It has many functions, such as relieving vasospasm and relieving inflammatory reaction.
Xuezhikang capsule, the main component of which is monascus, has the effects of removing turbidity, reducing blood lipid, promoting blood circulation, removing blood stasis, invigorating spleen and promoting digestion. It is used to treat hyperlipidemia caused by phlegm and blood stasis, with symptoms such as shortness of breath, fatigue, dizziness, headache, chest tightness, abdominal distension, loss of appetite, etc. It can also be used for adjuvant treatment of other cardiovascular and cerebrovascular diseases caused by hyperlipidemia and atherosclerosis.
At present, Xuezhikang capsule is widely used in clinic. The medicine is fermented by monascus, which is sweet and mild. "Compendium of Materia Medica" records that monascus "promotes digestion and blood circulation, strengthens spleen and dries stomach". Monascus is often used as a food supplement to improve blood circulation and reduce blood lipid. The results of modern medical research confirmed that monascus contains natural lovastatin and many essential amino acids. At present, the main components of monascus are mostly used to treat hypercholesterolemia, and its curative effect is directly related to lovastatin contained in its extract.
Lovastatin can decrease the plasma low-density lipoprotein cholesterol (LDL-C) level and increase the serum high-density lipoprotein cholesterol (HDL-C) reductase. By regulating and increasing the activity of low-density lipoprotein receptor on hepatocytes, the decrease of low-density lipoprotein level can be accelerated. Isoflavones and phytosterols in Xuezhikang capsules play complementary roles by enhancing the clearance of bile acids and reducing the absorption of intestinal cholesterol, respectively.
Therefore, the drug can regulate dyslipidemia, reduce blood cholesterol, triglyceride and low-density lipoprotein cholesterol, and increase high-density lipoprotein cholesterol; Inhibit the formation of atherosclerotic plaque; Protect vascular endothelial cells; Inhibit lipid deposition in the liver. Xuezhikang capsule is well tolerated by patients, which can provide clinical benefits for statins in the treatment of cardiovascular diseases. The combination of the drug and statins can optimize the dosage of statins, reduce the side effects caused by large doses of statins, and ensure the effectiveness and safety of patients.
In short, some scholars have found that the risk of coronary heart disease will be reduced by 1% every time the LDL-C level of patients is reduced, and adjusting the blood lipid index of patients can effectively reverse the progress of atherosclerosis. Taking lipid-lowering drugs is a common method to treat hyperlipidemia. The three drugs have single components and high safety, and can be used alone or in combination with other drugs according to specific conditions.