After two or more drugs cooperate with each other, it will produce inappropriate results such as reduced curative effect, failure and enhanced toxicity, which is called compatibility taboo. According to the nature of drug action, it can be divided into physical taboo, chemical taboo and pharmacological taboo. After two or more drugs are mixed, physical ejection such as separation, precipitation, deliquescence and liquefaction occurs, which is called physical compatibility taboo. After the two drugs are mixed, chemical reactions occur between the components, such as precipitation, discoloration, gas production, combustion or explosion, which is called chemical compatibility taboo. The two drugs have opposite effects, and the pharmacological effects of the drugs are weakened or offset when they are used together, which is called pharmacological compatibility taboo.
Contraindications of compatibility of traditional Chinese medicine
Generally, eighteen evils and nineteen fears are adopted.
The specific contents of the "eighteen antis" are: licorice, spurge, seaweed and Daphne genkwa; Radix Aconiti, Fructus Trichosanthis, Rhizoma Pinelliae, Radix Ampelopsis and Rhizoma Bletillae; Veratrum nigrum, Radix Adenophorae, Radix Salviae Miltiorrhizae, Radix Scrophulariae, Radix Sophorae Flavescentis, Asari and Radix Paeoniae. The specific contents of "Nineteen Fears" are: sulfur is afraid of nitrate, mercury is afraid of arsenic, wolfsbane is afraid of Lithuania, croton is afraid of morning glory, clove is afraid of turmeric, Sichuan aconite, wild aconite is afraid of rhinoceros horn, tooth nitrate is afraid of triangular prism, official laurel is afraid of halloysitum, and ginseng is afraid of trogopterum dung.
The above incompatibility can be used as a reference for medication, but it is not absolute. In the application of ancient and modern prescriptions, there are also some common usages. For example, the party involved in the use of Trogopterori can tonify the spleen and stomach and relieve pain, and it must be applied under the guidance of an experienced clinician.
Another song formula
Materia Medica clearly states eighteen kinds of contradictions.
Half-baked shells attacked Wu.
Algae and halberds are covered with fighting grass.
Ginseng, Xinshao, betrayed Veratrum.
What does the incompatibility of drugs mean!
Compatibility taboo refers to the physical and chemical reactions such as neutralization, hydrolysis, destruction and invalidation of drugs when two or more drugs are mixed or made into preparations. At this time, turbidity, stagnation, gas production, discoloration and other phenomena may occur. The compatibility of some drugs weakens the therapeutic effect of drugs and leads to treatment failure; The compatibility of some drugs enhances the side effects or toxicity, causing serious adverse reactions; There are also some drugs that make the therapeutic effect excessively enhanced, which is beyond the tolerance range of the body, and can also cause adverse reactions and even harm patients. These compatibility are taboo. Physical and chemical properties are intuitive phenomena! Pharmacology Pharmacological Compatibility Taboo refers to the phenomenon that after two or more drugs are compatible, their pharmacological effects are opposite, which reduces or even offsets their efficacy. There are many drugs that belong to this kind of incompatibility, such as central nervous system stimulants and central nervous system inhibitors, oxidants and reductants, laxatives and antidiarrheals, cholinergic and anticholinergic drugs. Therefore, only by correctly grasping the pharmacological effects of drugs can we avoid the occurrence of compatibility taboos in clinical medication; In addition, it must be understood that the incompatibility of such drugs also appears according to the situation of clinical medication, and sometimes it will be transformed. They are incompatible when they play a preventive role, but when a drug is poisoned, it is not incompatible to use drugs with opposite pharmacological effects to rescue it.
What do you mean by drug compatibility?
Compatibility of drugs In the process of drug manufacture or clinical use, mixing two or more drugs together is called compatibility. In compatibility, if there is a change that is not conducive to quality or treatment, it is called compatibility taboo. Appropriate drug compatibility can improve the performance of drugs and enhance the curative effect. If appropriate additives are selected to stabilize drugs, vitamin C can be added when ferrous salt is taken orally to increase absorption. However, compatibility taboos often occur. Compatibility contraindications can be divided into three categories: physical, chemical and pharmacological. Physical compatibility taboo refers to the change of physical properties when drugs are compatible. For example, some drugs will form a low melting point mixture after mixing, which will destroy the appearance and make it difficult to use. Taboo of chemical compatibility refers to chemical changes, precipitation, redox, discoloration reactions in the process of compatibility, which makes drug decomposition ineffective. Contraindication of pharmacological compatibility refers to the change of drug efficacy and the increase of toxicity after compatibility. Contraindication of drug compatibility means that when a drug is ineffective, other drugs need to be selected for reasonable compatibility. However, not all drug compatibility is reasonable, and some drug compatibility weakens the therapeutic effect of drugs and leads to treatment failure; The compatibility of some drugs enhances the side effects or toxicity, causing serious adverse reactions; There are also some drugs that make the therapeutic effect excessively enhanced, which is beyond the tolerance range of the body, and can also cause adverse reactions and even harm patients. These compatibility are taboo.
Contraindications of compatibility of prescription and medicine
The combination of two or more drugs is called compatibility of traditional Chinese medicine. Traditional Chinese medicines can take care of complex diseases in an all-round way through compatibility, and at the same time, make use of the synergy and antagonism between drugs to obtain safe and higher curative effect. After long-term understanding and practice, ancient physicians have accumulated rich knowledge of drug compatibility, which can be summarized into the following six aspects. (1) phase beard: that is, the combination of drugs with similar properties can play a synergistic role and enhance the curative effect. Such as gypsum and Anemarrhena asphodeloides, to enhance the efficacy of clearing heat and purging fire. (2) Matching: that is, drugs with different properties can be used together to promote each other and enhance the curative effect. If Astragalus membranaceus and Poria cocos are compatible, it can enhance the efficacy of benefiting qi and promoting diuresis. (3) Mutual fear: that is, the side effects of one drug can be alleviated or inhibited by another drug. For example, the toxicity of Pinellia ternata and Nanxing can be reduced or eliminated by ginger, so Pinellia ternata and Nanxing are afraid of ginger. (4) Mutual killing: that is, one drug can reduce or eliminate the side effects of another drug. Such as wind and arsenic, mung beans can detoxify croton, so wind and arsenic, mung beans kill croton. (5) Mutual antipathy: that is, when the two drugs are used together, they can contain each other and weaken or even fail. For example, ginger hates Scutellaria baicalensis Georgi and ginseng hates radish seeds. (6) On the contrary, the combination of the two drugs may produce toxic reactions or side effects. For example, aconite can prevent Pinellia ternata and licorice can prevent radish flowers. In the above six aspects, interdependence and interdependence belong to the synergistic effect of drugs; Fear and killing each other are antagonistic effects of drugs to varying degrees; Contradiction and opposition in drug compatibility taboo. In addition, there are some single drugs that play a role without the assistance of other drugs, such as Shen Du Decoction and other single drugs. In other words, the combination of the two drugs produces toxic and side effects or reduces or eliminates the curative effect. Predecessors have described eighteen opposites and nineteen fears. The so-called opposition refers to "opposition" and the so-called fear refers to "opposition". Eighteen anti-licorice, anti-kansui, spurge, thicken, seaweed. Radix Aconiti Lateralis Preparata, Bulbus Fritillariae Cirrhosae, Fructus Trichosanthis, Rhizoma Pinelliae, Radix Ampelopsis and Rhizoma Bletillae. Veratrum nigrum, Radix Adenophorae, Radix Salviae Miltiorrhizae, Radix Scrophulariae, Radix Sophorae Flavescentis, Asari and Radix Paeoniae. 19. Fear of sulfur and nitrate; Mercury is afraid of arsenic; Wolf poison is afraid of Tibetan monks; Croton is afraid of Petunia; Cloves are afraid of turmeric; Sichuan aconite and kusnezoff monkshood are afraid of rhinoceros horn; Tooth nitrate fears three shuttles; Guan Guiwei stone grease; Ginseng is afraid of trogopterori. The above compatibility taboos are for reference only, not absolute. In ancient and modern prescriptions, there are also examples of both opposition and fear. For example, the compatibility of kansui and licorice can better play the role of catharsis of kansui. This recipe can supplement the spleen and stomach and relieve pain by participating in the treatment of epigastric pain with Wuling Lipid, but the drug effect is not damaged. These problems need further study in the future. Taking certain drugs during pregnancy can cause fetal movement anxiety and even abortion. According to the degree of influence of drugs on the fetus, it can be divided into two categories: forbidden and cautious use. Most banned drugs are highly toxic or violent. Such as croton, aloe and senna; Daphne genkwa, kansui, spurge, Phytolacca acinosa and Petunia; Emetic melon and veratrum nigrum; * * * Be a sheep flower; Dry lacquer, rhizoma Sparganii, rhizoma Curcumae, Ferula Ferulae, leech and tabanus; Tongqiao medicine musk, toad venom and pangolin; Other highly toxic drugs such as mercury, arsenic, raw aconite, calomel, etc. Drugs used with caution are mostly potent or slightly toxic drugs. Such as rhubarb and mirabilite; Drugs for promoting blood circulation and removing blood stasis include peach kernel, safflower, frankincense, myrrh, cowherb seed, motherwort, trogopterori, etc. Tonifying stranguria and diuresis drugs: sunflower seeds and coix seed; Magnets to reduce bad drugs in important towns; Others such as Pinellia ternata, Arisaema, Calculus Bovis, Guanzhong, etc. All prohibited drugs should not be used, and drugs should be used with caution according to the situation of pregnant women. Try to avoid what can or can't be used to avoid accidents. (1) Eliminate impurities and non-medicinal parts, so that the drug is pure, accurate in dosage and reliable in curative effect. (2) change the drug performance and enhance the drug efficacy. For example, Rehmannia glutinosa is cold and cool, and it is slightly warm and nourishing when cooked; Polygonum multiflorum Thunb. It is used for relaxing bowels, nourishing liver and kidney and blackening hair after cooking. Pu Huangsheng is used to break blood and remove blood stasis, and decocted to stop bleeding; Corydalis yanhusuo vinegar enhances analgesic effect; Fried atractylodes can strengthen the spleen and strengthen the middle; The effect of Chaihu on relieving depression and soothing the liver is enhanced. (3) Reduce or eliminate toxic and side effects. For example, aconite and aconite are highly toxic products. After repeated soaking and boiling, toxic components are hydrolyzed and dissolved, and the toxicity is greatly reduced; Jiang Banxia and Alum South Star can reduce toxicity, and eliminate sore throat and emetic substances. Steam Ligustrum lucidum with salt water to remove its coldness and avoid diarrhea. (4) Correct taste and smell. Baking with honey, wine and vinegar usually has the effect of correcting taste and smell. For example, stir-fry with Oletum Trogopterori vinegar to remove odor. (5) Convenient preparation, decoction and storage. For example, shellfish are easy to be crushed after processing, and effective components are easy to be decocted; White mustard seed and radish seed were fried to remove the enzymes, and the effective components were preserved and not decomposed. (1) water method can make drugs clean, ......
What is the incompatibility and what is its practical value in clinical application?
Compatibility taboo means that one drug cannot be used with another drug or drugs at the same time, otherwise some adverse reactions will occur, such as adverse reactions, decreased curative effect and so on. Reasonable compatibility can enhance the therapeutic effect, showing a synergistic effect, and * * * can resist pathogenic microorganisms.