Expert: Abnormal liver function should not strengthen lipid lowering. Professor Sun, a special expert from the National Drug Evaluation Center, reminded the public today that the dosage of simvastatin, a commonly used drug for lowering blood lipid, should be determined according to the patient's cholesterol index and liver function status, and should not exceed 40mg； per day; Patients with poor liver function should not strengthen lipid lowering. The Adverse Drug Reactions Bulletin issued by the National Adverse Drug Reaction Monitoring Center last month said that recently, foreign drug delivery institutions found that the combination of simvastatin and amiodarone or the combination of high doses can increase the risk of rhabdomyolysis. Therefore, the US Food and Drug Administration advises doctors to inquire about the patient's past medical history and combined medication in detail before prescribing simvastatin, so as to clarify the benefits and risks of treatment; The daily dose of amiodarone should not exceed 20mg for patients receiving amiodarone treatment. If there is a risk of this interaction, other statins should be considered to replace it. Liu Jiaoshou, Department of Cardiology, People's Hospital of Xinjiang Autonomous Region, explained that amiodarone is a commonly used drug in clinical treatment of arrhythmia, and some patients use two drugs at the same time because of cardiovascular diseases such as hyperlipidemia and arrhythmia. Amiodarone can inhibit the metabolism of simvastatin in vivo and increase its concentration to produce muscle toxicity. Therefore, patients who take amiodarone should choose other statins if they want to reduce blood lipid. He stressed that at present, some doctors "intensify" the blood lipid reduction by giving patients a large dose of simvastatin (such as taking 80 mg every day), which makes its toxicity appear and increases the risk of rhabdomyolysis; This situation is especially serious for patients with poor liver function. He suggested that patients taking simvastatin for a long time should regularly check their liver function before and during medication, and stop using it immediately if the transaminase exceeds 4 times the normal value. As an expert in the prescription automatic screening system of the Ministry of Health, Professor Sun also reminded the public that besides amiodarone, simvastatin should not be taken at the same time with macrolide antibiotics, erythromycin and azole antifungal drugs, otherwise adverse reactions may occur; If you must take multiple drugs at the same time, it is best to consult a licensed pharmacist in advance. View original post >>