(1) usually begins to sneak attack, and the progress is slow. ① Irregular low-grade fever or intermittent headache often occurs at the initial stage of onset, and then it becomes persistent headache, which is gradually aggravated; ② Patients with low immune function can have an acute onset, often with fever, headache, nausea and vomiting as the first symptoms. The early symptoms are mainly that most patients have obvious meningeal irritation sign, and neck rigidity and Kernig sign can be seen on examination; ③ A few patients mainly have mental symptoms and local nervous system signs, which are irritability, personality change, memory loss, confusion and idiotic attacks.

(2) When a large granuloma accumulates in the brain, cerebellum or brain stem, it will cause quadriplegia and focal symptoms such as ataxia.

(3) Intracranial pressure increased due to traffic and/or obstructive hydrocephalus, and corresponding symptoms and signs appeared, such as papillae edema and optic atrophy in the later stage.

(4) Due to obvious exudation from the subarachnoid space at the bottom of the brain, arachnoid adhesion often causes most of the symptoms of brain nerve damage, often involving the auditory nerve, facial nerve and oculomotor nerve.