You can't use up one pill at a time. You poke a small hole with a needle, and the hole can retract itself. The rest can be used up in three days. Or put it in the refrigerator. I don't usually put it in the refrigerator.
It is best to rub it on acne marks, and of course, it can also be rubbed on the whole face. If you have oily skin, remember to dry the excess oil on your face with a hot towel after a full face massage.