Osbourne Cox (john malkovich), a former CIA agent, was finally kicked out of the house by the CIA because of his disorderly life, especially his old habit of drinking. As a result, old Cox also bears a grudge against the CIA, which he has served for many years. In order to get back at Cox, he recorded many scandals he heard in the CIA and made them into CDs. Just as he is planning revenge, the CD recording numerous CIA scandals is taken away by his wife Katie Cox (Tilda Swinton), who is divorcing herself.

More unfortunately, this CD was left in the gym by Katie, and finally fell into the hands of the slow fitness coach Chad Field Hammer (Brad Pitt) and gym employee Linda Leezke (Frances McDormand). After browsing the contents of the CD, two people with ulterior motives intend to blackmail the unlucky Osborne. At the same time, Harry Falar (George Clooney), an official who has been having an affair with Katie, commits the problem of philandering again, so he hooks up with Linda and gets involved in this chaotic extortion.