165438+1On October 4th, Messi appeared in a professional medical institution on the streets of Madrid for stem cell treatment. Only seven days after treatment, Messi flew from Europe to Uruguay in South America and played for the national team again, thus proving the effect of stem cell therapy.
The most direct influence of long-term sports training and competition on athletes is various knee joint injuries. According to foreign media reports, C Ronaldo and Gasol also cured their injuries through stem cells. Stem cell therapy can repair athletes' injured tendons and muscles, restore damaged parts and prolong athletes' sports career without any sequelae.
Knee joint, as the mainstay of lower limbs, is the largest and most complicated joint of human body, which plays the role of bearing and movement, and the cartilage covering it plays the role of absorbing pressure and reducing friction.
Although the knee cartilage is strong, it is easy to wear due to long-term weight bearing and frequent friction, leading to knee joint strain, which is the most common degenerative disease of the knee joint every day! ! !
Degenerative diseases of knee joint, also known as osteoarthritis, osteoarthropathy, degenerative arthropathy, senile arthritis, etc. , a common chronic osteoarthropathy, is characterized by the destruction of articular cartilage and the hyperosteogeny of articular margin and subchondral bone, which has certain disability.
The occurrence of knee joint degeneration is related to aging, inflammation, joint overuse, trauma, obesity and heredity. As of 202 1, degenerative diseases of knee joint have become the fourth most disabling disease.
Degenerative diseases of knee joint are also called "immortal cancer" because of its difficult and painful treatment. Early clinical manifestations are:
1, pain
Most patients have mild to moderate pain, mostly dull pain, accompanied by a sense of heaviness, soreness and stagnation, and the first diagnosis is discomfort.
2, swelling
Some patients have joint swelling and recurrent attacks.
3. Deformity
The knee joint can be varus or valgus deformity, and the joint bone margin is enlarged. Some patients can't completely straighten the knee joint, and in severe cases, the knee joint is deformed by flexion and contracture.
4, dysfunction
Abnormal movement rhythm: There may be leg weakness, clicking sound, rubbing sound and strangulation sound when the weight-bearing joint moves.
Weakening of exercise ability: the joints are stiff and unstable, the range of flexion and extension is reduced, and the functions of walking, squatting and going up and down steps are weakened.
At present, there are many conventional treatment methods for early knee osteoarthritis, which can be treated by drugs, physical therapy, minimally invasive, surgical joint replacement and other methods.
Some patients will choose surgical replacement after their condition deteriorates gradually. However, after surgical replacement, there are many complications such as wound infection and deep vein embolism because there is no blood vessel, nerve and lymphatic reflux in the cartilage of knee joint. At the same time, only cartilage tissue is highly differentiated, which can not promote the matrix composition of articular cartilage. However, the new tissue after cartilage repair is mostly fibrocartilage, and its function is worse than that of normal cartilage, which leads to the limited time of surgical effect and cannot be done once and for all.
Stem cell injection therapy is to inject stem cells with normal structure and function into joint cavity to repair knee joint injury and improve clinical symptoms.
It is mainly used to treat knee joint diseases caused by degenerative or repeated trauma and reshape the damaged knee joint.
Stem cells are pluripotent cells with the ability of self-replication. Under certain conditions, it can differentiate into a variety of functional cells. It has the potential function of regenerating various tissues, organs and human bodies, and is called "universal cell" in the medical field.
Self-differentiation, replication, proliferation and renewal of stem cells can repair irregular bone defects and cartilage defects, promote the increase of meniscus and bone volume, accelerate the healing of incomplete torn tendons and ligaments, improve joint function, and fundamentally treat knee joint degeneration.
Stem cells can secrete a large number of growth factors to promote tissue self-repair, at the same time secrete active factors, promote cell matrix components and angiogenesis, and improve joint cavity microcirculation.
Immune factors secreted by stem cells can indirectly regulate dendritic cells and natural killer cells, inhibit the proliferation of T lymphocytes, prevent T cell reaction and increase the secretion of anti-inflammatory factors, reduce the interaction between immune cells in the local microenvironment of joint cavity, promote the absorption of inflammatory edema and relieve pain symptoms.
On August 23rd, 20021year, the Korean research team announced that the world's first autologous stem cell drug for treating severe osteoarthritis through a single intra-articular injection had been formally submitted for a new drug application (NDA) and named after "Jointstem". If the application is successful, it is expected to be approved for listing in South Korea next year.
It is reported that the research and development cycle of JointStem is as long as 16. At present, the drug has been tested in phase 1, phase 2 (approved in 2008), phase 2b (approved in 20 14) and phase 3 clinical trials.
The second phase clinical trial has been approved by the US Food and Drug Administration and successfully implemented.
The third phase of this study was approved by Korea on 20/KOOC-0/9, and the third phase clinical trial of 252 patients was successful in all/KOOC-0/3 hospitals such as Kyung Hee University Hospital in Jiangdong, and it was successful in May 2002/KOOC-0/7.
The third-phase clinical study of the drug shows that stem cell therapy can improve knee joint function, relieve pain and regenerate knee joint cartilage.
At present, research teams at home and abroad have applied mesenchymal stem cells from different tissues to the clinical treatment of arthritis, and achieved remarkable results.
Relevant representative clinical trial results
At present, according to the National Medical Products Administration (NMPA), * * * three new stem cell drugs for the treatment of knee osteoarthritis have been clinically approved.
Stem cell therapy allows patients to grow knee chondrocytes, making degenerative arthritis a reversible disease.
In 2007, Rene Liu was diagnosed with "genu patella valgus". In order to treat her injured knee, she tried various methods.
20 12 at the doctor's suggestion, she tried autologous stem cell transfusion. In Weibo, she wrote: "I have tried every method in the world for my knee. Recently, there is a way to draw blood from my own artery, then cultivate my own cells and return them to my knees. I started treatment. "
China star Jason Wu has been injured because he has been making action movies for a long time. Knee arthritis is a long-standing problem in Jason Wu. In order to recover as soon as possible, Jason Wu went to Japan to inject stem cells to treat knee arthritis on 20 17, and recovered well.
From 20 17 to 12, 70-year-old Uncle Liu, who has a history of osteoarthritis for nearly 10, received the treatment of injecting mesenchymal stem cells into patellar bursa of knee joint, and his conscious pain disappeared obviously, his leg activity function improved obviously, and his sleep quality and mental state improved obviously. Pengcheng Evening News reported this case with the title "Mesenchymal stem cell transplantation technology creates a miracle of life".
Stem cell therapy, as the third generation of disease treatment after drug intervention and surgical intervention, has become a hot spot of research and application by scientists all over the world in the 2 1 century, which will bring a better future for human healthy life.