Blisters on the calf may be caused by burns on the calf, or papular urticaria caused by mosquito bites and mite allergies. At this time, you can generally pay attention to local disinfection to prevent secondary infection. If you are burned, you need to apply MEBO in time to prevent the development of inflammation and infection. If it is caused by insect bites, temporarily apply calamine lotion or some glucocorticoid ointments, such as dexamethasone cream and hydrocortisone butyrate cream. And oral antihistamine to relieve itching.