(2) Immune factors: Host immunity plays an important role in the progress of human papillomavirus infection and pathological changes. It was found that the infection rate of human papillomavirus in immunosuppressants after renal transplantation was 17 times that of normal people. The infection rate of human papillomavirus among HIV-infected people has also increased. Due to the chaotic sexual behavior of HIV-infected people, a large number of sexual partners and the younger age of their first sexual behavior, the probability of human papillomavirus infection has increased. However, some studies cannot prove that there is a direct correlation between immunosuppression and human papillomavirus infection. Because of the high risk of self-exposure or the reduced ability of the body to resist latent virus, the HIV population may increase the infection rate of human papillomavirus. The detection level of HPV DNA in this population is higher than that in the normal population, indicating that the ability of the body to inhibit HPV infection is reduced.
(3) Pregnancy: Studies show that the number of pregnant women, the number of deliveries and the number of miscarriages will not increase the risk of human papillomavirus infection, but the number of teratomas is related to human papillomavirus infection. Studies have shown that the infection rate of human papillomavirus in pregnant women is high, and the amount of virus detected also increases, but this may be due to the increase of virus level during pregnancy, which improves the detection efficiency. A study of detecting human papillomavirus by PCR confirmed this view. The detection of human papillomavirus by PCR has nothing to do with the virus content, and there is no significant difference in infection rate between pregnant women and non-pregnant women (9.6%/ 10.9%).
(4) Oral contraceptives: Although oral contraceptives will increase the risk of cervical cancer, it is still controversial whether it affects human papillomavirus infection. Studies have shown that oral contraceptives do increase the probability of human papillomavirus infection, but some people think that oral contraceptives have no effect on the occurrence of low-grade cervical lesions, but will increase the risk of high-grade cervical lesions. Therefore, oral contraceptives are considered to change the course of the disease rather than directly affect the infection rate of human papillomavirus.