2 English reference Fugui Bawei Pills
3 Description of Fugui Bawei Pill 3. 1 Drug Name Fugui Bawei Pill
3.2 Medicine Chinese Pinyin Fugui Bawei Pill
3.3 Fugui Bawei Pill is alias Cui Shi Bawei Pill; Bawei pill; Bawei Dihuang Pill
3.4 classification of endocrine system drugs > Chinese patent medicine
3.5 dosage form: 9g per pill, each box 10 pill; Tablets: each tablet contains 0.5g of crude drug, and each bottle contains 500 tablets; Oral liquid: each tablet 10ml, each box 10 tablets; Capsule: each capsule contains 0.5g of crude drugs, and each bottle contains 100 capsules.
3.6 The main components of Fugui Bawei Pill are Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Rhizoma Dioscoreae, Corni Fructus, Alismatis Rhizoma, Poria and Cortex Moutan.
3.7 Pharmacological effects of Fugui Bawei Pill: lowering blood sugar, lowering blood fat, enhancing immunity, improving endocrine, scavenging free radicals, diuresis and lowering blood pressure.
1. Pharmacological action (1) Lowering blood sugar When the prescription is given to adult rats at a dose of 5 times or 10 times that of human, the glucose tolerance curve is improved and the blood sugar value is recovered faster. This prescription can improve the sugar assimilation function of aged rats or mice and increase the insulin secretion of islets. The powder made from the decoction pieces of this prescription and various single crude drug powders that make up this prescription have inhibitory effects on the water consumption, urine volume and urine sugar content of STZ diabetic rats, while the granules only have inhibitory effects on urine sugar content, and only Cornus officinalis has inhibitory effects on water consumption. (2) Enhance immune function and tuberculin reaction. There were 65,438+03 patients with non-immune diseases whose tuberculin reaction was negative or suspected positive. After taking this prescription, intracutaneous reactivity showed that tuberculin reaction was enhanced. In addition, the elderly over 65 years old are classified as Bawei Pill syndrome group, and the tuberculin reaction is also obviously enhanced after taking this prescription. In vitro experiments show that this prescription can improve the function of mouse macrophages, make the phagocytosis rate and phagocytosis index higher than those of the control group, and significantly increase the formation of hemolysin antibodies. Normal saline extract has no obvious factors, but it can regulate the proportion of lymphocyte subsets in the elderly, prevent the decline of IgG in the elderly, increase IgM and improve complement activity. After applying this prescription to 30 outpatients who complained of burnout, it was found that the number of CD 16 (P < 0.05 = and CD 57 (P < 0.0 1) positive cells (a lymphocyte) with natural killer cell activity increased significantly. (3) Discussion on the Effect of Administration on Glutathione Metabolism; The glutathione metabolism, reduced glutathione (GSH) and oxidized glutathione (GSSG) contents, GSH and GSSG in rats were determined by fluorescence method. The results showed that GSH and GSSG of experimental cataract lens in animals decreased obviously, which led to the change of transparency. Jinkui Shenqi Pill can prevent cataracts caused by the decrease of GSH content in crystals with age. This prescription can also significantly increase glutathione and GSSG in the lens of patients with cataract and ophthalmopathy, suggesting that this prescription has therapeutic effect. In addition, it is reported that GSH and GSSG in testis have also increased, and GSH is related to DNA synthesis. It is speculated that this recipe has certain influence on the formation of hormones and * * * *. (4) The effect on blood lipid and atherosclerosis. This method can reduce the hyperlipidemia of quail feeding, including high triglyceride and high cholesterol, and has a tendency to reduce the lipid in the liver, heart and aorta of ddy mice fed with high cholesterol, which can obviously improve the aging lipid metabolism and low lipid metabolism in the liver caused by long-term use of ethanol. Long-term administration tends to reduce the contents of calcium, phosphorus, magnesium and 34 calcium binding capacity in the aorta of ddy mice fed with high cholesterol, and at the same time reduce the content of collagen, which shows that this prescription has the effect of preventing atherosclerosis. In addition, it has been reported that high-density lipoprotein increased significantly after taking this prescription. At the same time, the atherosclerosis index can also be improved, so this prescription will also have a good impact on the improvement of atherosclerosis. (5) The action of active free radicals. The production of active free radicals is a reaction to foreign bodies. It plays an immune protection role in killing foreign bodies, but excessive production leads to membrane lipid peroxidation, which is related to aging, autoimmune diseases, tumors and so on. 1989 Yao reported that Jinkui Shenqi Pill increased the activity of superoxide dismutase in blood and brain homogenate of mice, decreased the content of malondialdehyde in brain and adrenal gland, and had the effect of scavenging free radicals and peroxides. It is also reported that Jinkui Shenqi Pill can reduce MDA in skin and serum of aged rats, increase SOD, promote free radical metabolism, reduce cell damage caused by free radicals and reduce lipid peroxidation caused by hyperlipidemia, thus making this prescription have the effects of treating diseases and resisting aging. (6) Effect on peripheral circulation With the increase of the age of rats, the number of cells with high specific gravity increases, and their deformability decreases, which can be obviously inhibited after the prescription is given. At the same time, the ATP content, lipid membrane composition and surface charge of red blood cells were determined, and the prescription also had good results. The fingertip volume pulse, which marks the peripheral blood flow, was measured in patients over 65 years old with numbness of hands and feet. All patients increased, and the symptoms were relieved after taking this prescription. It can also be seen that this prescription has a strong improvement effect on microcirculation system when treating diabetic patients. Further experiments show that Cinnamomum cassia has the function of relaxing central and peripheral blood vessels and improving microcirculation and sensory disturbance. (7) Influence on Autonomic Nervous System In diabetic or non-diabetic patients who are effective in this prescription, the related indexes of autonomic nervous system, such as RR interval change of electrocardiogram, Valsalva ratio, standing hypotension, grip strength test and nerve conduction velocity, were observed before and after taking the medicine, and all improved after taking the medicine. (8) Effects on Endocrine Metabolism Animal experiments show that Fu Gui Shenqi Pill can correct the weight loss, weakness or failure of mice caused by high-dose hormones, indicating that Fugui Bawei Pill can improve the functions of pituitary and adrenal cortex. Further research on the crude drugs in this prescription shows that Cortex Moutan, Fructus Corni and Ramulus Cinnamomi have the effect of inhibiting adrenocortical hormone, and Cortex Moutan also has the effect of enhancing insulin. Some people also use this prescription to treat patients with bronchial asthma with Bawei Pill syndrome. Look at this prescription. It has adrenocortical hormone-like effects. (9) Improvement of renal function and diuretic effect: If the dosage of this prescription is 65,438+00 times that of adults and rats are fed for 65,438+0 months, urine output will increase and urinary sodium ion excretion will increase, but the excretion of zinc, magnesium and calcium ions has no obvious change, and the ions in plasma are within the normal range. Analysis shows that Rehmannia glutinosa, Alisma orientalis, Poria cocos and Fuzi all contain diuretic components. The extract can increase serum albumin, reduce urine protein and serum urea nitrogen in mice with IgG accelerated nephrotoxicity nephritis, and may improve renal tissue lesions by reducing plasma lipid peroxide content. For patients with urea nitrogen100 ~110 mg/dl, complete loss of renal function, high edema and limb weakness, the symptoms can be improved after taking this prescription, and the urea nitrogen is reduced to 25mg/dl, and the renal function gradually recovers. (10) The prescription of anti-aging can not only delay aging, but also restore energy. Its mechanism, besides overwhelming the heart, may also have the function of reviving whole body cells. Some people pointed out through animal experiments that the reason why this prescription can "rejuvenate" may be that it acts on the body with comprehensive efficiency, and its effects of improving sugar, protein and fat metabolism are intertwined. At the same time, it effectively plays an anti-aging role by scavenging free radicals and peroxides. Effect of (1 1) on blood pressure This prescription can reduce the content of norepinephrine in the serum of hypertensive rats induced by high fructose, thus lowering the blood pressure of rats. Experiments in spontaneously hypertensive rats (SHR) show that this recipe can obviously reduce the blood pressure of SHR, reduce the hydroxyproline content in left ventricular wall and thoracic aorta, increase the excretion of urinary kallikrein and improve the disease manifestations. The effect of (12) on sex hormones shows that this recipe can promote the production of testosterone in testis. For 10-week-old rats 1630-hour oestrus II and1/0/00-hour pre-oestrus follicles, this recipe secretes progesterone before ovulation.
2. Indications: Warming and tonifying kidney yang. Indications are deficiency of kidney-yang, soreness of waist and knees, cold sensation of lower limbs, small abdominal distension, urgency, edema, dysuria or frequent urination, impotence, enuresis, weakness of ulnar pulse, expectoration, cough, thirst, beriberi, etc.
3. Toxicity test: Chronic toxicity test was carried out on rats with suspension made of Fugui Bawei Pill extract powder and 5% Arabic gum solution, with the dosage of 40,200, 1000 mg/kg. Observe for 6 months. Results There was no effect on general state, weight, water intake, food intake and peripheral blood picture. There is no abnormality in the main organs by naked eye and histological examination. Some biochemical indexes of rats in 1000g/kg group changed, and the wet weights of lung, kidney, thyroid gland, adrenal gland and pituitary gland were lower than those in the control group. The results show that this prescription is toxicologically safe in common doses, but it is suspected that high doses will increase transaminase, dehydrogenase and neutral fat.
4. Adverse reactions People with weak digestive function will have loss of appetite or vomiting, diarrhea, and some will have urticaria. This is mainly caused by rehmannia glutinosa, which may be avoided by taking wine as a mirror. In addition, it is reported that 1 case of allergic reaction caused by oral administration of Jinkui Shenqi Pill showed itching all over the body, red maculopapular rash with paroxysmal palpitation, and EKG showed sinus arrhythmia, which disappeared after stopping taking the drug, and the above symptoms reappeared after stopping taking the drug.
3.8 Indications of Fugui Bawei Pill 1. (1) Fugui Bawei Pill was used to treat chronic glomerulonephritis 10 cases, 4 cases were completely and basically relieved, 3 cases were improved, and good curative effect was achieved. Six cases were treated with Xue's modified recipe, which could make edema gradually subside, urine volume increase, urine protein disappear or decrease, and renal function improve. Blood pressure drops. This recipe treats renal edema 12 cases, among which 3 cases were treated with Wupi drink orally, and 10 cases were cured. Generally, it takes effect after taking medicine for 2 weeks. According to the symptoms, 39 cases of uremia were treated with Angong Niuhuang Pill or Zhibaodan combined with western medicine, and 8 cases survived/kloc-0. (2) Chronic urethritis: Except for a few cases who were treated with Tori Disinfection Drink or antibiotics in a short period of time, all the other cases were cured and the cytological examination was negative. (3) Postpartum urinary retention: 465,438+0 cases were treated with this recipe or Jisheng Shenqi Pill. If the parturient is in poor health and lacks vitality, ginseng and radix astragali should be added. Postpartum patients with mild cold and fever should first use Xinping to relieve the cold, and then use the above prescription to urinate. There is no cure. Among them, 23 cases (55.5%) took 1 dose, and 12 cases (85.5%) took two or three doses to urinate. (4) Benign prostatic hyperplasia: This prescription of Jialongteng Decoction has satisfactory curative effect, and all patients aged 65 ~ 8 1 year are cured by this method. Another report reported the curative effect of Bawei Pill on 56 cases of prostate syndrome, including prostatic hyperplasia, bladder neck sclerosis, prostatitis and neurocystitis. The effective rate of patients who complained of dysuria was 46.9%, and the effective rate of patients with frequent urination and nocturnal urination was 36%. (5) Refractory enuresis: 1 female, 9 years old, enuresis for 5 years. Take one tablet in the morning and one tablet in the evening. After taking pills above 10, nocturia is reduced to 1 ~ 2 times, and you can wake up on your own and urinate only once every five days. After taking 80 pills, the chronic disease was cured within 5 years and there was no recurrence within 2 years. All children with deficiency syndrome were treated with Fugui Bawei Pill, and several cases have been cured. (6) Elderly urinary incontinence: 13 cases of elderly urinary incontinence were treated with this prescription, taking 2 capsules with light salt water every morning for 10 days. After 4 courses of treatment, 6 cases were cured, 4 cases were markedly effective, 2 cases were improved and ineffective 1 case, with a total effective rate of 92.3%. (7) senile inflammation; Eight elderly patients with amenorrhea for more than 8 years were treated with this recipe, 7.5g daily, taken three times. Four weeks later, among the 8 patients with spontaneous symptoms, 6 cases disappeared, 2 cases were relieved, lumbago and numbness of hands and feet, 4 cases all disappeared, and burnout disappeared 1 case. * * * Endoscopic examination showed that red spots on * * * wall and * * * cervix disappeared in 6 cases, and relieved in 2 cases. The total effective rate was 100%. (8) Male Infertility and Decline of * * *: Among 52 male infertile patients whose * * * concentration is lower than 40× 103/ml,1pregnancy was successful, 55.8% of them had clinical effect, and most of them had effect in the early 4-8 weeks. The follow-up results of * * * concentration in 27 cases (pregnant and non-pregnant patients) showed that the concentration of * * * in 18 cases (55.6%) increased by more than 3 times. For 76.5% patients with * * * deficiency (10 ~ 40×103/. Only 30% (3/ 10× 103/ml) of patients with * * * short height are clinically effective. Judging from the clinical effectiveness, this prescription has no obvious improvement on the exercise rate of * * *. The values of luteinizing hormone (LH), prolactin (PRL) and testosterone (T) in peripheral blood hardly changed before and after treatment. In the effective group, follicle hormone (FSH) decreased (P < 0.05) and estradiol (E2) increased (P < 0.00 1). The results show that this prescription is effective in the early stage of hypogonadism, and has direct or indirect influence on spermatogenesis, adnexal gland or endocrine environment. Some people use this prescription to drink ginseng soup, which also has a good effect on this disease. (9) Male mammary gland development: For 32 male patients with * * * development, decoct with this prescription, daily 1 dose. After 60 days, 23 cases were markedly effective, 7 cases were effective and 2 cases were ineffective, and the total effective rate was 93.7%. Patients with short course of disease and young age have better effect. (10) Erectile dysfunction: It is effective in treating this disease, and has obvious curative effect on mental factors, and has obvious effect on enhancing erectile power. It is effective for deficiency syndrome and emaciation with kidney deficiency as the main factor, but it is not only ineffective for obesity, but also has many side effects. (1 1) Treatment of gynecological diseases: 10 This recipe was used to treat the brocade belt caused by deficiency of kidney-qi, wind-cold and weakness of chong and ren, and all of them were cured. (12) Hyperprolactinemia infertility: For 27 female infertility patients with blood prolactin > 30 ng/ml, this prescription was given 2.5 g ~ 10g every day for more than 3 months, and the serum prolactin of 18 patients decreased, among which 15 patients had normal level.
2. Diabetes generally has moderate physical strength or below, weak abdomen, stable symptoms and light thirst. After taking the medicine, the blood sugar often drops gradually and the symptoms are relieved. It is considered that about 60% ~ 70% of diabetic patients are suitable to take this prescription. Six cases of diabetic neuropathy were treated with this pill extract, 5 ~ 6g daily for 3 months. According to the improvement degree of comprehensive consciousness symptoms, 2 cases were effective and 2 cases were slightly effective. It has been reported that the ginseng in this prescription has obvious curative effect on diabetic patients and can reduce the amount of insulin injection.
3. Achyranthes bidentata and Semen Plantaginis can be added to the hypertension prescription, which is suitable for patients with kidney yin deficiency and kidney yang deficiency. Uncaria, Cortex Cinnamomi, Flos Chrysanthemi and Rhizoma Gastrodiae can be added for dizziness, and Vitex negundo, Concha Haliotidis, Prunella vulgaris and Scorpio can be added for headache. Pueraria lobata can be applied to the back neck, Cortex Moutan can be reused to treat arteriosclerosis, and Alisma orientalis, Polygonum Multiflori Radix and Semen Cassiae can be reused to treat cholesterol. Treating hypertension 1 1 cases with Fugui Bamei pill essence or decoction has obvious curative effect.
4. In 44 cases of cataract, most of them were treated with this prescription. Of the 82 eyes, 68 eyes improved, 8 eyes remained unchanged, and 93% eyes improved and stopped declining. Another 284 patients were not accompanied by diabetes, nephritis and other diseases, and there was no obvious change in fundus and anterior part of eyes. The total effective rate was 72.2%, and the total effective rate of 568 eyes was 865,438 0.4%. It can be seen that this prescription has a good effect on improving and preventing the development of senile cataract. It has also been reported that this prescription can increase the elasticity of the patient's eyeball, reduce the white opacity of the lens and improve vision. The sooner the medicine is given, the better the curative effect will be. It is observed that this prescription has also achieved good results in treating presbyopia.
5. Bronchial wheezing is equivalent to cough, wheezing and wheezing in Chinese medicine. 107 cases of bronchitis and wheezing treated with western medicine were treated with traditional Chinese medicine. In principle, take 5g of Chinese medicine extract twice a day in the morning and evening. Among them, Bawei Pill syndrome accounts for 365,438+0.8% (adrenocortical steroids are commonly used in western medicine), and the effective rate is 76%. Prescription: Take 1 capsule twice a day (9g per capsule) to 100 capsules. When asthma stops and the rest symptoms disappear, take about 200 pills to consolidate the curative effect. Follow-up for 3 years did not recur. In recent years, some people have used this prescription to treat refractory asthma. Due to repeated attacks of asthma, the lung and kidney will decline, and the inspiratory function will decline, resulting in deficiency of both qi and blood, and Yang will easily die. After treating kidney deficiency syndrome with this prescription, the curative effect is obvious, and the improvement rate of this disease is 65% with other Chinese medicine prescriptions.
6. Ascites XXII. Patients with advanced schistosomiasis whose ascites has not healed for a long time have impaired renal function, and urine tests have proteins, casts, red blood cells and white blood cells. Take Fugui Bawei Pill (30g daily) to consolidate the foundation, then treat the symptoms with saliva mercury (daily 1 pill), and then take this prescription to consolidate the foundation. Due to the interaction, all ascites subsided. After the ascites was eliminated, 17 cases were treated with antimony, of which 15 cases completed the course of treatment. Sodium antimony tartrate is effective in the treatment of renal damage caused by schistosomiasis, and 5 cases have achieved good results, which is helpful for schistosomiasis patients to complete antimony treatment.
7. Use this prescription to treat edema twice a day. 9g each time, 65438 02 cases of edema were treated, including 3 cases of edema of lower limbs. Combined with Wupi Decoction, there were 10 cases cured, and 2 cases were ineffective (with hookworm disease, anemia and schistosomiasis ascites). The longest treatment time is 90 days and the shortest is 2 1 day. Generally, after taking medicine for 2 weeks, symptoms are relieved, urine volume is increased, and edema is gradually subsided.
8. Low back pain 12 chronic low back pain patients aged 55-80, the effective rate was 83.3%. In addition, this prescription was given to 10 patients who complained of low back pain, and its analgesic effect and its influence on endocrine function were observed. The effective rate of pain relief was 60%.
9. Osteoporosis For outpatient menopause, 27 patients with osteoporosis with a score above 4 were screened out by micro-density measurement (MD). After 6 months and 65,438+02 months of treatment with the extract and VD2, the total MD score of 65,438+09 of 27 cases decreased, among which 6 cases decreased to the normal range of less than 3 points, and 265,438+0 cases (78%) increased their bone mass.
10. For 26 patients with gastrocnemius spasm more than 65438 0 times per week, 7.5g of this prescription was given every day for more than four weeks. After 1 week, 9 cases disappeared, 16 cases disappeared and 10 cases improved, all of which were effective. Among them, 5 effective patients were randomly selected for vibration perception threshold examination, and the results showed that all of them were significantly improved after medication.
1 1. 15 gouty arthritis patients used this soup once a day 1 time, and the course of treatment was more than two weeks. 4 cases of acute arthritis improved, 9 cases of chronic arthritis improved and 2 cases were ineffective, with a total effective rate of 86.66%.
12. This prescription and self-made rubella wine (facial alkali 15g, borneol 5g, white wine 50ml) were used for external treatment of acute and chronic urticaria 10 cases, all of which were cured. When taking medicine for chronic urticaria, taking Xiaomi decoction can improve the curative effect. In addition, Fugui Bawei Pill has improved 4 cases of senile deformed knee joint disease, and 65,438+05 cases of bone tuberculosis were cured and 2 cases were improved. This prescription also has obvious curative effect on patients with mild and moderate mental retardation through two opposite mental effects of will activation and anti-anxiety. It has certain curative effect on diabetes insipidus, nephrotic syndrome, glomerulonephritis, retinal hemorrhage, glaucoma, tuberculosis, eyelid twitch, anemia, insomnia, salivation, chronic low fever, chronic abdominal mattress, etc. It also has obvious curative effect on sciatica, and it can obviously reduce the number of attacks and the dosage of nitroglycerin when combined with western medicine, such as Xintongding and thiabenpirone, to treat angina pectoris.
3.9 Precautions: People with weak digestive function can cause loss of appetite or vomiting, diarrhea, and some have urticaria.
3. 10 Fugui Bawei Pill Usage and Dosage: 9g each time, 2-3 times a day, taken with warm boiled water or light salt water; Or decoct in water, reduce that dosage according to the original prescription, or making into granules or pow. Tablets: 6 tablets at a time, taken orally twice a day. Oral liquid: take 1 tablet once, twice a day. Capsules: Take orally, 5 capsules at a time, twice a day.
3. 1 1 Expert opinion