Due to the complex and typical geographical environment and special climatic conditions, the Zhuang inhabited areas have created very rich medicinal resources. According to the investigation of 1983 ~ 1987, there are as many as 4,623 kinds of Chinese herbal medicines in Guangxi Zhuang Autonomous Region (including 4,064 kinds of plant medicines, 509 kinds of animal medicines and 50 kinds of mineral medicines), ranking second in the country. Among them, there are 709 kinds of drugs commonly used in Zhuang medicine (according to the statistics of Guangxi National Medicine Outline). Since 1993, the Research Office of Medicinal Plant Resources of Guangxi Institute of Ethnic Medicine has undertaken the scientific research project of "General Survey and Development and Utilization of Zhuang Medicine Resources" issued by state administration of traditional chinese medicine, further carried out the general survey of Zhuang medicine in the whole region, and found 397 new species of Zhuang medicine. Therefore, there are more than 1000 Zhuang medicines in Guangxi alone.

Zhuang medicine has a long history. Some varieties of Zhuang medicine were developed and utilized earlier, and at the same time they became famous Chinese medicines. For example, "The Biography of Ma Yuan in the Later Han Dynasty" said: "When going out, crossing your toes, the soil is full of miasma." Because you often take coix seed, you can prevent dysentery. Then bring it back to the Central Plains. Coix lachryma-jobi seed is still a commonly used medicine for Zhuang medicine, and it is also a commonly used Chinese medicine. It is rich in counties in Baise area where Zhuang people live in concentrated communities. Among the cultural relics unearthed from the Han Tomb in Radish Bay, Gui County, there are some commonly used drugs of Zhuang medicine such as Kuding tea and honeysuckle. Among the 365 kinds of drugs included in Shennong Herbal Classic, Yin Gui, Gui Mu, Coicis Semen, Cinnabar, Stalactite and so on are abundant in Zhuang areas. There are 125 kinds of "folk prescriptions" in this book, which have the functions of "dispelling cold and heat, breaking accumulation and treating diseases" and are mostly produced in Zhuang areas. The newly revised Materia Medica in the Tang Dynasty also contains many potent drugs, such as gallbladder, talc, cinnamon, poria cocos, cinnamon, garlic, cucurbitacin, black stone fat, gelsemium, rattan snake yellow, turmeric, sappan wood, wolf postscript and so on. In a short time, "Materia Medica" included Chen Jiabai and Ganjia Baiyao, the famous antidotes of Zhuang medicine at that time, and presented them to the court as tributes.

As mentioned above, the wide application of poisons and antidotes is an important feature and highlight of Zhuang medicine. In addition, the advanced method of burning mercury with cinnabar and the discovery and utilization of Tianqi should also become an important symbol of the development and utilization of Zhuang medicine to a certain level.

"Notes on Materia Medica" says that cinnabar comes from Fuling, but in fact, the gold-wrapped sand leaked from Rongzhou, especially from Tanzhou, is the top grade. The Song Dynasty's Answer to the Generation Outside the Ridge recorded in detail the method of burning and refining mercury by the ancestors of Zhuang nationality: "Yong people used alchemy sand as mercury, iron as the upper and lower pots, the upper pot was filled with sand, separated by fine-eyed iron plates, the lower pot was filled with water and buried underground, and the second pot mouth was sealed on the ground, and burned with blazing fire. The cinnabar water turned into mist and fell after being mixed with water. This sealed distillation method, which conforms to the scientific principle, has been recorded earlier in the history of natural science.