Safety of probiotics
When it comes to who is not suitable for taking probiotics, we are actually talking about the safety of probiotics.
Common probiotics (lactic acid bacteria, bifidobacteria) are recognized as safe food (GRAS); GRAS is an index for FDA to evaluate the safety of food additives. The strains in the List of Edible Fungi Species published in China are all within the scope of GRAS, so probiotics are generally considered to be safe.
As a manufacturer of probiotics, before the listing of probiotics, in order to ensure that everyone will not be poisoned, the relevant safety assessment was carried out.
So what screening criteria should probiotics have? Briefly introduce:
1, the source of bacteria should be healthy intestines and traditional fermented food;
2. Identification of strains (pathogenic genes);
3. Analysis of harmful metabolites: endotoxin, hemolysin, nitrite, D- lactic acid, biogenic amines, aromatic amines, etc.
4. Antibiotic tolerance: antibiotic-free tolerance is an increasingly important indicator, mainly to prevent the emergence of superbugs;
5. Adhesion: Adhesion is an important indicator for probiotics to play a role, which is controversial, but some scholars believe that too strong adhesion may increase the pathogenic risk of probiotics;
6. Hypersensitivity;
7. Bile salt dissociation and gastrointestinal mucosa shedding;
8. Animal experiment: acute toxicity experiment; Chronic toxicity test; Reproductive toxicity test;
9. Human trials.
Side effects of probiotics
Therefore, a lot of experiments were done before probiotics went on the market to ensure that everyone had no problem eating them. Isn't it safe to sit down and relax?
Probiotics may still have side effects on some special people! The main problem is still focused on "infectivity", that is, whether probiotics enter the blood will cause sepsis or other related diseases.
Unfortunately, although our probiotics are basically tested for infectivity through animal experiments, there are still many probiotics that may be related to Lactobacillus and Bifidobacterium. Or other local or systemic infections, such as endocarditis and septicemia related to lactic acid bacteria intake.
What kind of people are not suitable for taking probiotics?
Simply put, there are two kinds of people:
1, severely immunocompromised and immunocompromised
2. People with intestinal barrier problems
Both types of people need to be cautious when taking probiotics, and it is best not to take them. However, according to the current statistics, the infection rate of probiotics in this group of people is very low, and many scholars think that these side effects are sporadic.
Which groups are not recommended to take it?
Immunodeficiency patients, premature infants, patients with short bowel syndrome, patients with central venous catheter, elderly patients, patients with congenital heart disease and heart valve disease, patients with intestinal surgery in convalescence, patients with malignant tumors, patients with severe inflammatory bowel disease, and patients with ascites due to cirrhosis.
Most people can eat it.
In fact, we really don't have to panic about the side effects of probiotics, because according to the current data, the infectivity of probiotics can be summarized as follows:
1. At present, the clinical infection cases involving lactic acid bacteria are all from the sick people, especially those with impaired immune system;
2. No infection cases related to lactic acid bacteria were observed in healthy people or pregnant women;
3. Compared with the normal population, no more lactic acid bacteria-related infections were observed in the population exposed to high doses of lactic acid bacteria for a long time;
4. At present, there are no cases of infection caused by eating fermented food, probiotics or drugs containing probiotics under normal circumstances;
5. The infectivity of probiotics is related to strains, and not all strains are highly contagious.
Junda's multi-active bacteria are selected from the original plant-derived strains of Taoist health holy places such as Qingcheng Mountain, Pengzu Mountain Mountain and Laojunshan Mountain. They contain 5 probiotics, 3 prebiotics and 65,438+0 dietary fibers. Each bag/kloc-0.00 billion live bacteria directly colonize the stomach and intestines. Taking the first glass of water together every morning can regulate intestinal flora, significantly improve constipation, diarrhea, allergies, gastrointestinal discomfort and other symptoms, which is very important for prevention and treatment.