From 65438 to 0989, Yan Xijun was transferred to the No.254 Hospital of the People's Liberation Army as the director of the medical machinery department, responsible for the procurement of medical equipment and drugs, as well as the supply and management of drugs. At that time, the hospital funds were more difficult, and the medical machinery department funds were even less. For the development of the hospital, the pressure of the medical machinery department naturally falls mainly on Yan Xijun's shoulders. It is obviously impossible and unrealistic to rely only on the limited funds of superiors. Find the hospital leader, the leader said, you want money, don't; If you want policies, you can give them and engage in "independent development, internal introduction and external exchanges." This sentence lit a lamp in Yan Xijun's heart.
In order to find the source of income, Yan Xijun engaged in a variety of businesses, but all failed. He didn't make any money, but he learned a lesson. Finally, he decided to return to his old job-pharmacy. This time, he turned his attention to Chinese medicine with profound historical and cultural accumulation and devoted himself to the development of compound Danshen dropping pills, a modern Chinese medicine.
This is a road full of hardships and challenges. For thousands of years, the dosage form of traditional Chinese medicine has been "pill powder paste Dan soup", but he insists on concentrating the efficacy of a medicine on a few dripping pills as big as rice grains, which is hard to say! However, Yan Xijun will never give up easily.
Without funds, the difficulty of starting can be imagined. Wu Feng, a comrade-in-arms and lover, gave him firm support. Lack of technical information, they study together; Without technical standards, they personally tested over and over again: humidity, temperature, viscosity, content, stability, effectiveness, and safety ... just like Tang Priest had to go through 81 difficulties, countless sleepless nights, and the pain of countless failures ... When they spit out small particles like black pearls in the pill machine they designed, the couple raised their hands emotionally. "Success! We succeeded! " When the development of compound Danshen dripping pills achieved initial results, another idea came to Yan Xijun's mind. He wants to turn this achievement into a product and put it on the market. The new drug certificate of Compound Danshen Dripping Pills is still in the application process, so he wants to "find a delivery room first, not a fetus" and plans to build a 5,000-square-meter modern medicine building, with the main building cost of more than 8 million yuan.
The news spread, and a stone stirred up a thousand waves! Many people say that Yan Xijun is "crazy". At that time, according to the establishment regulations of the military hospital, the 254 hospital and its superiors could only invest 6.5438+0.4 million yuan in the preparation room, but the remaining 7 million yuan, plus equipment investment, was nearly/kloc-0.0 million yuan, which required Yan Xijun to raise funds by himself. Not only is the huge funding gap a difficult problem, but what is even more difficult is that due to insufficient funds, the plan to build a building cannot be approved and launched.
Yan Xijun instinctively felt that this was another major challenge in his life. He firmly believes that compound Danshen dripping pills have great development prospects. Because he knows that there are about 400 million people suffering from coronary heart disease in the world, and the annual death toll exceeds 65.438+0.2 million! Coronary heart disease has become the "first killer" of human beings, and ancient Chinese medicine will certainly make great achievements; The modernization project of traditional Chinese medicine, which the country has begun to brew, will be accelerated, and the ancient Chinese medicine will have a bright future. If we don't seize the opportunity at this time and hurry up, we will delay the fighter plane and be irresponsible for our cause!
My wife Wu Feng always supports him firmly at critical moments. In order to find funds, the couple traveled between major pharmaceutical companies in Beijing and Tianjin every day and invited them to participate in the stock market. Heaven rewards hard work, and their sincerity has been rewarded. Finally, they found their investment partner, Tianjin Central Pharmaceutical Factory, and solved some valuable funds.
His persistence was also strongly supported by Dong, director of the barracks department of the logistics department of the Beijing Military Region at that time (now the director of the logistics department of the Beijing Military Region). His plan of "overall design and step-by-step implementation" reasonably solved the "deadlock" of temporary lack of funds, and Yan Xijun actively strived for it, and the preparatory building was finally approved for the project.
The completion of the preparatory building made the soldier Yan Xijun show the other side of his talent. As long as he is not on a business trip, he is "long" on the construction site almost every day, from design to construction, from procurement to feeding. Even if it is a steel bar or a bag of cement, he must be careful. His comrade-in-arms smiled and said to him, "Your old man has never been so careful with his son!" " Looking at the beautiful modern medicine building that is getting taller every day, Yan Xijun feels extremely excited.
1The building was built at the end of 993. After many tests, applications, verification and clinical trials, Compound Danshen Dripping Pills also successfully obtained the national new drug certificate and production number. At the same time, a dropping pill production line with advanced technical performance and technological process has been built. The predecessor of Tasly Group-Angel Force United Pharmaceutical Company was born in May 1994.
The listing of new drugs is only the first step in the long March. If you want to turn it into a commodity, you have to "climb the snow-capped mountains", "cross the grassland" and "rush to cross the Dadu River" ... But "bitterness" and "difficulty" are nothing to Yan Xijun, and many years of military career have already created his character of being hard-working and daring to fight hard. In order to run the market, his thin mouth thickened his feet and led his comrades to fight a tough battle. A city, a city, a hospital and a hospital do propaganda, have tasted all kinds of hardships, experienced all kinds of risks and traveled all over the country-provinces, cities and counties. After more than half a year's efforts, the market finally smiled at Yan Xijun, and hospitals and pharmacies began to fill drugs into eight boxes, ten boxes, three boxes and five boxes. The production and sales of compound Danshen dripping pills have entered a stage of rapid development.
Then, good news and honor followed. 1995 sales revenue reached160,000 yuan, 1996 reached 27 million yuan, 1997 exceeded 80 million yuan. "Compound Danshen Dripping Pills and Its Series Research" won the second prize of military scientific and technological progress and the third prize of national scientific and technological progress successively, and was included in the national "Ninth Five-Year Plan" major scientific and technological achievements promotion project and the national 973 basic scientific research project.
1998, Yan xijun experienced an unforgettable and unforgettable period! At the beginning of the year, the Beijing Military Region established the Beijing Military Region Pharmaceutical Group (division-level establishment) with Tasly as the core enterprise, and Yan Xijun served as the general manager of the group. Just as Yan Xijun was full of ambition and was ready to do a big job in the military and pharmaceutical industry, the military region conveyed the decision of the Central Military Commission of the Party, demanding that the troops stop all production and business activities and decouple enterprises from the troops! Obeying orders is the first duty of a soldier! "Where to go? Is it to take off the military uniform and embark on a difficult road to entrepreneurship, or to stay in the army and bid farewell to the' Tasly Group' that you have painstakingly managed? "
Both the army and Tasly Force are Yan Xijun's "lifeblood", and Yan Xijun encountered the first dilemma in his life!
The leader of the military region said to him: "The army will reduce its staff, but it will not reduce its talents. You are an excellent person in the army, so you can stay. It's up to you to stay or not. " The implication is full of retention.
Comrades advised him, "You have been in length of military service for so long. You not only won the second class merit, but also won the scientific and technological awards from the army and the state. You are both a senior professional and an expert enjoying special allowance from the State Council. It would be nice to stay in the army for a lifetime. " He knows that his comrades-in-arms are all for his own good
That night, he tossed and turned, stayed up all night, and the scenes of his military camp career were replayed in his mind. ...
The next morning, he made a bold decision: don't ask the army for an official position, don't talk to the army about conditions, take off his military uniform and go into business!
The army leader said with concern, "Old Yan, aren't you digging your own grave?" Even if you don't want a place to arrange work, at least you have to retire and get hundreds of thousands of resettlement fees! "
Yan Xijun said affectionately: "I am an orphan. /kloc-come to the army at the age of 0/6. It was the army that trained me to grow up and gave me everything now. My roots have been rooted in the military camp, and my soul will always belong to the military camp. However, nowadays Tasly is just a small sapling, and we people have the responsibility to cultivate it. Even the unfinished task that the army gave me as a veteran! "
Under his leadership, the 47 cadres and volunteers who founded Tasly with him made no demands on the organization and collectively took off their military uniforms and went to sea. How to lead thousands of employees in the future? How to develop enterprises? All this needs to be answered in "breaking" and "creating".
Although the original military-run enterprises did not enjoy any preferential tax policies, the salaries of cadres and volunteers were guaranteed by the army, which could ensure the success or failure of the enterprises. Self-management, self-financing, self-support. Yan Xijun knows that the huge risks facing the market must be borne by Tasly, which is still immature; Only by changing everyone's thinking from the traditional concept of "ensuring the harvest through drought and flood" and firmly binding everyone's interests with the fate of enterprises can we mobilize everyone's intelligence and enthusiasm for work to the maximum extent and let the ship "Tasly Force" break the waves in the ocean of market economy. To this end, he proposed to carry out joint-stock reform of enterprises in accordance with the requirements of modern enterprise system.
The proposal met with strong opposition as soon as it was put forward. Someone asked: "If we invest in shares, if the enterprise loses money, won't we lose everything?" At the restructuring conference, Yan Xijun made a generous statement: "Enterprises will have no future without restructuring; If everyone is not tied to a warship, it will be difficult for enterprises to develop well. If the enterprise loses, I will lose everything like everyone else! It is not the style of our soldiers to worry about losing before the war, and to worry about compensation if enterprises can't do it! What is the style of soldiers? The style of soldiers is to dare to fight and win, persevere, bear hardships and stand hard work, and go forward bravely. Only in this way can our enterprise survive and develop! " He also solemnly asked everyone: "The equity restructuring of enterprises is both an opportunity and a challenge for everyone. We must strictly abide by national policies and regulations, and we can neither borrow money from our enterprises nor institutions. We just have to shoulder this debt ourselves, put pressure on ourselves and move forward with heavy burdens. "
Tasly's shareholding system reform has been strongly supported by the Tianjin Municipal Party Committee and Municipal Government, and it is agreed that Tasly will be restructured in full accordance with the modern enterprise system. Yan Xijun and his wife Wu Feng took the lead and took out all their savings to buy shares in the company. His comrades-in-arms and most of the backbone also took shares. It is with the support of Tianjin Municipal Party Committee and Municipal Government, with the active promotion of Yan Xijun, and with these adventurous entrepreneurial spirits that Tasly has entered the fast lane of modern enterprise development.
The long-term military career has created Yan Xijun's superb art of organization and management and the strategic courage of the commander-in-chief, which has been fully exerted in the practice of enterprise management.
Since 1996, the state has vigorously promoted the implementation of the strategy of modernization and internationalization of traditional Chinese medicine. Yan Xijun is keenly aware of the great development potential brought by this opportunity to Chinese medicine enterprises and the strong impact on the Chinese medicine industry.
Yan Xijun clearly remembers the profound experience of visiting the United States with a corporate delegation organized by state administration of traditional chinese medicine. The long-term backwardness of China's pharmaceutical industry makes Chinese people know little about foreign pharmaceutical markets. He thinks that the United States is a country with high incidence of heart disease, and compound Danshen dripping pills will definitely have a market there. It was only in the United States that it was discovered how difficult it was for Chinese medicine to enter the mainstream market as a medicine in this highly developed country! At that time, no Chinese medicine company's products were certified by the US Food and Drug Administration (FDA). Traditional Chinese medicine products of a few large enterprises are sold as health care products or food on the containers of grocery stores in Chinese areas. Yan Xijun's compound Danshen dripping pills with him are rarely taken care of.
This is an unforgettable memory deeply hidden in Yan Xijun's heart!
Chinese medicine is the quintessence of our country. Both Japanese and Koreans can use "foreign Chinese medicine" to make money all over the world. Why can't we in China? A strong sense of national pride and military mission inspired and spurred him: the sacred mission of revitalizing Chinese medicine has historically fallen on the shoulders of our generation. If we can't introduce Chinese medicine to the world, we will be ashamed of our ancestors and future generations!
With this heavy sense of mission, Yan Xijun is actively looking for a good opportunity to enter the international market! It is also saving the strength to enter the international market!
1996 in the second half of the year, the state selected excellent varieties of traditional Chinese medicine nationwide to hit the international market. Compound Danshen dripping pills stand out among many competing products. Yan Xijun immediately set out to prepare a scientific research report and submitted an application to the US FDA for compound Danshen dripping pills to enter the US market as a drug.
He chose a road full of ravines and thorns for himself!
The reason why Chinese medicine is difficult to enter the international market is actually very simple. First of all, the cultural traditions of the East and the West are different, so it is difficult for foreigners to accept the basic theories of TCM, such as "Yin-Yang and Five Elements" and "Four Qi and Five Flavors". In their view, the liver is the liver and the kidney is the kidney. Where is Yin? Where is Yang? Don't admit anything you can't see. Secondly, the way of "expression" in Chinese medicine is backward, except that soup is a big pill, foreigners dare not eat it. Third, western medicine is chemical and its composition is clear; Traditional Chinese medicine is empirical medicine, which was explored by our ancestors bit by bit according to experience. As for how to treat this disease, it is not clear which component of the drug works. Fourth, medicinal materials are mainly plants that grow under natural conditions. Even for the same herb, there are great differences in medicinal components due to different regions, climate, hydrological conditions and planting management. It is difficult to control the quality of traditional Chinese medicine preparations produced with such medicinal materials.
What shall we do? Yan Xijun said, the road should be taken step by step, and the fortresses should be conquered one by one.
Yan Xijun is a man of great understanding. He is keenly aware that thanks to the vigorous promotion of the country, the modernization of traditional Chinese medicine will inevitably have a diversified development situation. Broad vision, active thinking, systematically thinking about the development direction of Chinese medicine industry. The modernization of traditional Chinese medicine production technology has become the consensus of the industry. On the basis of TCM innovation, he put forward a new concept of "modern TCM". Guided by the theory of traditional Chinese medicine, modern Chinese medicine uses modern advanced techniques of planting, extraction, separation, enzymolysis and preparation to remove toxic components from medicinal materials, and uses effective substances composed of various active components or monomers to make preparations, and uses multiple fingerprints and chromatographic techniques to qualitatively and quantitatively reach the international standards of botanical drugs. According to this theory, Yan Xijun put forward "three innovations". First, technological innovation, the development of advanced dropping pills equipment, fully automatic technological process, the use of advanced extraction technology, to maximize the extraction of effective components of Chinese herbal medicines, to achieve the combination of modern pharmaceutical technology and traditional Chinese medicine theory; The second is dosage form innovation, that is, it is necessary to change the traditional dosage forms of big soup and big pill, and use advanced molecular dispersion technology to make Chinese medicine achieve "three small" (small volume, small dosage and little toxic and side effects), "three effects" (high efficiency, quick effect and long effect) and "five convenience" (convenient production, storage, transportation, carrying and taking). The third is standard innovation, which adopts advanced technologies such as high performance liquid chromatography and infrared spectroscopy to monitor product quality, realize qualitative and quantitative analysis of compound preparations of traditional Chinese medicine, make the quality, efficacy and safety of traditional Chinese medicine in line with international standards, and clear the obstacles for traditional Chinese medicine to enter the international market.
In the process of developing modern Chinese medicine, Yan Xijun strongly realized that the internationalization of Chinese medicine must build an integrated modern Chinese medicine industry chain that meets international standards. After strict investigation and systematic research, Tasly established the first GAP-compliant drug source base in Shangluo, Shaanxi. Initiated and established the Quality Management Standard (GEP) for the extraction and production of modern traditional Chinese medicine and plant medicine; For the first time in China, the international advanced multi-fingerprint quality control technology was applied to monitor the whole process of drug quality, which realized the integration of the digitalization of modern Chinese medicine with the world quality standards of botanical drugs.
It is Yan Xijun's unshakable belief to push the Chinese medicine industry into the era of modern industrial civilization and onto the advanced platform of modern manufacturing technology. IT is the first in China to put forward "building a digital platform for advanced manufacturing of modern Chinese medicine", and successfully developed the largest production line of dropping pills and outer packaging in China by using IT technology and intelligent control. A modern traditional Chinese medicine production demonstration base conforming to GMP was born. On the one hand, we are solidly building the basic project of modern Chinese medicine, and on the other hand, we are firmly grasping the international market. Although the US market threshold is high, it is by no means insurmountable. After several years of trekking, inspection and communication, Yan Xijun gradually found a way to enter the American pharmaceutical market.
In the following years, Yan Xijun traveled to and from the United States many times. In the spacious conference room of the FDA building in the United States, facing more than 20 critical American pharmaceutical experts and scholars, Yan Xijun and his team of experts had a clear thinking, and Kan Kan Kan Kan talked: "As a cultural treasure in the world medical treasure house, Chinese medicine has made great contributions to human health in the past history. Now, with the continuous advancement of the modernization of Chinese medicine, we are willing to share the best Chinese medicine products with the American people ... "In the subsequent defense, Yan Xijun answered all the questions of American experts on the efficacy, technology and quality inspection methods of Compound Danshen Dripping Pills.
After a series of audits, the FDA's examiners solemnly announced that Compound Danshen Dripping Pills were approved to pass the FDA-IND application and enter Phase II and III clinical research! Yan Xijun listened carefully to the translation. Before he finished listening, he was overwhelmed by a burst of warm applause ... This scene was deeply fixed in Yan Xijun's mind. He is excited and proud of it. He seems to have broken through the hard ice of winter and seen the dawn of Chinese medicine spring!
199865438+1October 12 The National Leading Group for the Coordination of New Drug Research and Development, composed of 18 ministries, held a working meeting in Beijing, officially announcing that Tasly Compound Danshen Dripping Pills became the first compound Chinese patent medicine in China that passed the clinical trial of FDA-IND cardiovascular new drugs, achieving a "zero breakthrough" in traditional Chinese medicine.
Yan Xijun's success in the first battle in the United States strengthened his determination to open up the international market and introduce Chinese medicine to the world. He wrote two old sayings of China into his motto: "The road is long, but it is Xiu Yuan, so I will go up and down" and "Where there is a will, there is a way". Since then, Yan Xijun, like an indomitable walker, has started the journey of galloping the world pharmaceutical market, covering five continents. On the one hand, the entry of Compound Danshen Dripping Pills into FDA should be unswervingly promoted. In addition to the international standards, it is more important to be in line with the humanistic environment and language methods. This is an arduous task; On the other hand, the international market development of generic drugs should be further developed. Tasly branches and offices have been established in France, Netherlands, Australia, South Africa, Central Africa, West Africa, Russia, Vietnam, South Korea, United Arab Emirates and other countries. Tasly modern Chinese medicine, represented by compound Danshen dripping pills, has also successfully entered the pharmaceutical market in 34 countries such as Russia, South Korea and Singapore as prescription drugs or health care drugs. In April 2004, Yan Xijun wrote another wonderful stroke in the history of Tasly: Tasly successfully registered more than 400 batches of traditional Chinese medicine granules in the Netherlands and entered the pharmaceutical market of 25 countries in the European Union in one fell swoop!
Tasly not only pays attention to independent innovation, but also pays attention to the establishment and improvement of intellectual property protection system, and has established a set of protection measures such as "core patents, peripheral patents and defense patents" to make every effort to build an internationally renowned brand, so that the influence of Tasly brand continues to expand on a global scale.
Every Monday, when the golden sun rises from the horizon, Tasly Group headquarters and Tasly branches and offices around the world will hold a solemn flag-raising ceremony in the footsteps of the sun. The five-star red flag of China and the flag of Tasly Group are flying in the blue sky of foreign countries, forming a beautiful scenery, which makes every Chinese people feel heroic. In many countries, consumers who take delicious modern Chinese medicine to restore their health, whenever they get together, "Long live China!" The laughter of "I Love Tasly" makes people deeply feel the gospel brought by China's "national medicine" to people all over the world.
Tasly has come all the way from the storm after 1 1 year of entrepreneurship. The total assets have grown from120,000 yuan to 5 billion yuan, the number of employees has increased from more than 40 to 5,500, from a small factory with several acres of land to a modern Chinese medicine city with 1300 mu, and the products have expanded from the Chinese medicine industry economy to the big health industry. Compound Danshen Dripping Pills has made great achievements, setting a miracle that the sales of a single variety of traditional Chinese medicine exceeded 654.38 billion yuan for four consecutive years. In 2005, Tasly was recognized by the State Administration for Industry and Commerce as a "well-known trademark in China" and became the first brand of modern Chinese medicine.