Vitamin E (tocopherol): Long-term use of large doses (above 100 mg per day) can cause various nonspecific discomfort. Those who use it for more than 6 months are likely to cause adverse reactions such as platelet aggregation and thrombosis. When the daily dose is more than 400 mg and the dose is more than 1 year, especially when combined with estrogen, the chance of inducing thrombophlebitis is greatly increased.