Seronegative spondyloarthropathy (SpA) is a group of immune diseases mainly involving arthropathy and involving multiple systems. In the early 1970s, Wright and Moll collectively referred to arthritis with negative serum rheumatoidfact and RF (RF serum-negative arthritis. Because this group of diseases is easy to be complicated with spondylitis, it is also called seronegative spondyloarthropathy. At present, it is considered that this group of diseases includes ankylosing spondylitis (AS), Wright syndrome, ankylosing spondylitis (PsA), reactive arthritis (ReA), inflammatory bowel disease, childhood spinal arthropathy and a group of so-called "undifferentiated spinal arthropathy" with uncertain classification. The diseases in this group have the following characteristics: ① family aggregation tendency; ② It is different from HLA-B27 gene; ; ③ There are many similarities and overlaps in clinical manifestations; ④ Peripheral arthritis is often a prominent manifestation in the course of disease; ⑤ Rheumatoid factor is negative (accurately speaking, the positive rate of rheumatoid factor is similar to that of normal people); ⑥ No rheumatoid subcutaneous nodules; ⑦ There are different degrees of sacroiliitis; ⑧ The lesions are mainly around the tendon end and the part where the ligament is attached to the bone (inflammation at the attachment end), and can also occur in the eyes, aortic valve, lung parenchyma and skin, which is different from rheumatoid arthritis with synovial lesions as the main part.

It can't be completely cured, but it can control the disease, prevent the disease from developing further and prevent the attack.