The concentration of serum creatinine mainly depends on these two conditions: glomerular filtration rate and creatinine production in vivo. Age will affect the renal creatinine filtration rate, but the difference between 35 and 70 years old is only (105-70)/ 105, which is about 33%, while the creatinine clearance rate of healthy adults is 80 ~ 120 ml/min, which is also 33%. Therefore, with the increase of age, although the creatinine clearance rate has decreased, it can not be used to judge the damage of renal function within the normal range.
It is even more nonsense to judge that painkillers cause renal function damage according to creatinine clearance rate. In European and American societies, these non-narcotic antipyretic and analgesic drugs are over-the-counter drugs and can be bought in ordinary supermarkets. About 40% people take it regularly all the year round, and there is no obvious statistical data of renal damage, otherwise the FDA would have controlled it.
In order to calculate the creatinine clearance rate, it is necessary to measure serum creatinine. The greater the value, the lower the creatinine clearance rate. The diet and muscle metabolism of fitness people far exceed that of the general population, and their endogenous creatinine is also greater than that of the general population, so the calculated creatinine clearance rate will be lower than that of the general population. But this does not mean that glomerular filtration function is impaired, and it is reversible.
Jacky's figure and posture show that he is a master of fitness, and his skill is very vigorous, unlike a patient with impaired renal function at all. So if his creatinine clearance rate is low, it is more likely to be caused by his diet and exercise. Of course, if he needs to further clarify renal function, he needs to control diet, exercise and drugs, and then measure blood creatinine, urea and uric acid, as well as urine protein, urine creatinine and glomerular reabsorption function.