I use tretinoin for external use. I didn't use the right method. It was irritating at first. When I establish tolerance, I use toothpicks to apply to my acne, which means I can only use a little. I'll just apply it with my finger. After using it for a while, the acne didn't get better. My face began to be allergic. I went to the hospital all the time, and then I used a whole tube of tacrolimus to get better. I haven't used facial cleanser since I was allergic.