2. At first, backache, weakness (fatigue), frequent urination, edema of ankles or eyelids, and loss of appetite. In the middle stage of development, the skin is black, prone to colds and fever, anemia, proteinuria, occult blood, creatinine greater than 200, blood lipid, blood pressure, urea nitrogen, uric acid and so on. Significantly increased, joint pain, cutaneous purpura, diabetes insipidus. At the later stage of development, the whole body aches, itches, vomits, has severe anemia, creatinine is higher than 400, oliguria or anuria, and the mouth smells of ammonia.

3. It is suggested that western medicine find out the situation and actively treat it with integrated traditional Chinese and western medicine.