The pathogen in COVID-19 has mutated. The reason for the serious epidemic situation in Tengzhou is the variation of pathogens in COVID-19. By the end of 2022, on the 7th day of Tengzhou 19 epidemic1.24 in Shandong Province, 15 cases had been added. Among them, 2 confirmed cases were detected in the centralized isolation point, and asymptomatic infected people 13 were detected in the centralized isolation point.